Clinical Investigation

Kidney International (1981) 20, 97–103; doi:10.1038/ki.1981.110

Renal filtration fraction, effective vascular compliance, and partition of fluid volumes in sustained essential hypertension

G M London1, M E Safar1, J A Levenson1, A C Simon1 and M A Temmar1

1Hemodynamic Laboratory of the Hypertension Research Center, Hôpital Broussais, Paris, France

Correspondence: Prof A M Safar, Hopital Broussais, 96 rue Didot, 75674 Paris, Cedex 14, France.

Received 14 February 1980; Revised 10 September 1980.

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Abstract

Renal filtration fraction, effective vascular compliance, and partition of fluid volumes in sustained essential hypertension. Extracellular fluid volume, hemodynamic parameters, total effective compliance, and renal indices were measured in 58 patients with sustained essential hypertensive in comparison with 56 normotensive subjects of the same age and sex. All subjects had a balanced sodium intake and urinary output with inulin clearance and extracellular fluid volume within normal ranges. In patients with hypertension, the ratio between plasma volume (PV) and interstitial fluid volume (IFV) was decreased (P < 0.01) and was negatively correlated with the filtration fraction (FF) (r = -0.43; P < 0.001). Total effective compliance was significantly reduced (P < 0.001) and was positively correlated with the PV/IFV ratio (r = 0.73; P < 0.001) and negatively correlated with FF (r = -0.56; P < 0.001. The study provides evidence that the relationships between PV/ IFV, FF, and vascular compliance reflect an alteration of the postcapillary segment of the circulation in hypertension.

Fraction de filtration rénale, compliance vasculaire effective, et partition des liquides extra-cellulaires chez les hypertendus permanents essentiels. Le volume des liquides extracellulaires, la compliance vasculaire effective et les paramètres hémodynamiques et rénaux ont été mesuréschez 58 hypertendus permanents essentiels, en comparaison avec 56 sujets normotendus de même age et de même sexe. Tous les sujets ont une balance sodée équilibrée, ainsi que des valeurs normales de la clearance de l'inuline et du volume des liquides extracellulaires. Chez les hypertendus, le rapport entre le volume plasmatique (VP) et le volume du liquide interstitiel (LI) est réduit (P < 0.01). Il est négativement corrélé à la fraction de filtration rénale (FF) (r = -0.43; P < 0.001). La compliance effective totale est significativement réduite (P < 0.001). Elle est positivement correlée au rapport VP/LI (r = 0.73; P < 0.001) et négativement correlée à FF (r = -0.56; P < 0.001). Ce travail suggère que les relations observées PV/LI, FF et la compliance vasculaire effective reflètent un trouble du segment post-capillaire de la circulation dans l'hypertension artérielle essentielle.

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