Kidney International (1981) 19, 317–323; doi:10.1038/ki.1981.22
Sexual dysfunction in the male patient with uremia: A reappraisal
Warren R Procci1, David A Goldstein1, Janice Adelstein1 and Shaul G Massry1
1Division of Nephrology, Department of Medicine and the Department of Psychiatry, the University of Southern California School of Medicine, Los Angeles, California
Correspondence: Dr S G Massry, Division of Nephrology, Department of Medicine, University of Southern California, School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033, USA
Received 10 March 1980; Revised 4 June 1980.
Top of pageAbstract
Sexual dysfunction in the male patient with uremia: A reappraisal. Partial or complete impotence is common in uremia. It is not clear whether the impotence is organic or psychogenic in nature and whether uremia itself or the state of chronic illness is responsible for it. We examined these questions, by psychiatric interviews and nocturnal penile tumescence (NPT), in 50 normal subjects, 48 patients with chronic uremia, including 23 patients treated with maintenance dialysis, and 22 patients with chronic illness and normal renal function. About 40 to 50% of patients with uremia, but not those with chronic illness and normal renal function, complained of erectile dysfunction and reported a significant decrease in frequency of intercourse. There were no significant differences between patients with uremia prior to initiation of therapy and those treated with maintenance hemodialysis. NPT declines after 40 years of age. In all age groups, NPT was significantly (P < 0.01) lower in uremics than in normals or those with chronic illness. There was no correlation between erectile complaints, frequency of intercourse or NPT, and the presence or absence of depression. The frequency of intercourse correlated significantly (r = 0.68, P < 0.01) with NPT in patients with uremia. Data indicate that 50% of male patients with uremia have partial or complete impotence, which is most probably organic in nature and is related to uremia or its metabolic or hormonal consequences rather than to the state of chronic illness.
Disfonctionnement sexuel chez le malade urémique de sexe masculin: Une réévaluation. L'impuissance partielle ou totale est fréquente au cours de l'urémie. La nature organique ou psychogénique de l'impuissance n'est pas claire et il n'est pas non plus établi si l'urémie par elle même ou la maladie chronique en sont responsables. Nous avons étudié ces prodromes chez 50 sujets normaux, 48 malades atteints d'urémie chronique, parmi lesquels 23 étaient traités par hémodialyse itérative., et 22 malades atteints d'affections chroniques, mais avec des fonctions rénales normales au moyen des interrogatoires psychiatriques et des érections nocturnes. Quarante à cinquante pour cent des malades urémiques, mais non pas ceux atteints de maladies chroniques avec des fonctions rénales normales, se sont plaint d'anomalies de l'érection et d'une diminution significative de la fréquence des rapports sexuels. Il n'a pas été observé de différence significative entre les malades urémiques non traitées et ceux soumis à l'hémodialyse. Les érections nocturnes dominent à partir de 40 ans. Dans tous les groupes d'age les érections nocturnes sont significativement (P < 0,01) moins fréquentes chez les urémiques que chez les sujets normaux ou les sujets atteints d'autres maladies chroniques. Il n'a pas été observé de corrélation entre la fréquence des rapports sexuels ou les érections nocturnes et la présence ou l'absence de dépression. La fréquence des rapports est significativement corrélée (r = 0,68; P < 0,01) à celle des érections nocturnes chez les sujets urémiques. Les résultats indiquent que 50% des malades urémiques males ont une impuissance partielle ou totale qui est très probablement d'origine organique et liée à l'urémie ou à ses conséquences métaboliques ou hormonales plutôt qu'à l'état de maladie chronique.
Top of pageReferences
- Friedman EA, Goodwin NJ, Chaudry L: Psychosocial adjustment of family to maintenance hemodialysis. Part II. NY State J Med 70:767–774, 1970
- Foster FG, Cohn GL, McKegney FP: Psychosocial factors and individual survival on chronic renal hemodialysis: A two year follow-up. Part I. Psychosom Med 35:64–82, 1973 | PubMed | ISI | ChemPort |
- Levy NB: Sexual adjustment to maintenance hemodialysis and renal transplantation: National survey by questionnaire. Preliminary report. Trans Am Soc Artif Intern Organs 19:138–143, 1973
- Abrans HS, Hester LR, Sheridan WF, Epstein GM: Sexual functioning in patients with chronic renal failure. J Nerv Ment Dis 160:220–226, 1975
- Levy NB: The quality of life on maintenance hemodialysis. Lancet 1:1328–1330, 1975
- Salvatierra O, Fortmann JL, Belzer FO: Sexual function in males before and after renal transplantation. Urology 5:64–66, 1975 | PubMed |
- Sherman FP: Impotence in patients with chronic renal failure on dialysis: Its frequency and etiology. Fertil Steril 26:221–223, 1975
- Thurm J: Sexual potency of patients on chronic hemodialysis. Urology 5:60–62, 1975 | Article | PubMed | ChemPort |
- Bommer J, Tschope W, Ritz E, Andrassy K: Sexual behavior of hemodialyzed patients. Clin Nephrol 6:315–318, 1976
- Steele TE, Finkelstein SM, Finkelstein FO: Hemodialysis patients and spouses: Marital discord, sexual problems and depression. J Nerv Ment Dis 162:225–237, 1976 | PubMed | ISI | ChemPort |
- Bergsten E, Asaba H, Bergstrom J: A study of patients on chronic hemodialysis. Scand J Soc Med 11:1–31, 1977
- Milne JF, Golden JS, Fibus L: Sexual dysfunction in renal failure: A survey of chronic hemodialysis patients. Int J Psychiatry Med 8:335–345 1977 –78
- Kaplan De-Nour A: Hemodialysis: Sexual functioning. Psychosomatics 19:229–235, 1978
- Procci WR, Hoffman KI, Chatterjee SN: Sexual functioning of renal transplant recipients. J Nerv Ment Dis 166:402–407, 1978
- Kinsey AC, Pomeroy WB, Martin CE: Sexual Behavior in the Human Male. Philadelphia, WB Saunders, 1948
- Karacan I, Williams RL, Thornby JI, Salis PJ: Sleep-related tumescence as a function of age. Am J Psychiatry 132:932–937, 1975 | PubMed | ChemPort |
- Beck AT: The Diagnosis and Management of Depression. Philadelphia, University of Pennsylvania Press, 1973
- Feighner JR, Robbins E, Guze SB, Woodruff RA, Winokur G, Munoz R: Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26:57–63, 1972 | PubMed | ChemPort |
- Beck AT, Ward CH, Mendelson M, Meck J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 4:561–571, 1961 | PubMed | ISI | ChemPort |
- Raskin A, Schulterbrand J, Reatig N, Rice CE: Factors of psychopathology in interview, ward behavior, and self-report ratings of hospitalized dépressives. J Consult Psychol 31:270–278, 1967 | PubMed |
- Karacan I: A simple and inexpensive transducer for quantitative measurements of penile erection during sleep. Behav Res Meth Instrumen 1:251–252, 1969
- Karacan I, Salis PJ, Ware JC, Dervent B, Williams RL, Scott FB, Attia SL, Beutler LE: Nocturnal penile tumescence and diagnosis in diabetic impotence. Am J Psychiatry 135:191–198, 1978
- Fisher C, Schiavi RC, Edwards A, Davis DM, Reitman M, Fine Y: Evaluation of nocturnal penile tumescence in the differential diagnosis of sexual impotence: A quantitative study. Arch Gen Psychiatry 36:431–437, 1979
- Reichsman F, Levy NB: Problems in adaptation to maintenance hemodialysis: A four-year study of 25 patients. Arch Intern Med 130:859–865, 1972