Symposium on Drug Effects on the Kidney

Kidney International (1980) 18, 609–622; doi:10.1038/ki.1980.179

Renal effects of drugs that inhibit prostaglandin synthesis

Michael J Dunn and Edward J Zambraski

Department of Medicine, Division of Nephrology, Case Western Reserve University, University Hospitals, Cleveland, Ohio, and Department of Physiology, Rutgers University, New Brunswick, New Jersey

Correspondence: Dr M J Dunn, Department of Medicine, Division of Nephrology, Case Western Reserve University, University Hospitals, Cleveland, Ohio 44106, USA.

Received 29 May 1980.

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Abstract

There is extensive, clinical use of antiinflammatory drugs that inhibit prostaglandin synthesis in most, if not all, organs in the body. Much of the therapeutic efficacy of these agents depends on a reduction of prostaglandin synthesis at the site of inflammation. Not surprisingly, many of the side-effects of these drugs are secondary to decreased prostaglandin synthesis in brain, vasculature, stomach, lung, and kidney. In this review, we will focus attention on the effects of these antiinflammatory compounds on renal function, with particular emphasis on renin secretion, control of renal blood flow (RBF), and glomerular filtration rate (GFR). To describe these renal consequences of prostaglandin inhibition, we will briefly review the biochemistry of prostaglandin synthesis and the major known physiologic actions of prostaglandins in the kidney.

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References

  1. Samuelsson B, Goldyne M, Granstrom E, Hamberg M, Hammarstrom S, Malmsten C: Prostaglandins and thromboxanes. Ann Rev Biochem 47:997–1029, 1978 | PubMed | ChemPort |
  2. Larsson C, Anggard E: Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney. Eur J Pharmacol 21:30–36, 1973 | PubMed |
  3. Hassid A, Dunn MJ: Microsomal prostaglandin biosynthesis of human kidney. J Biol Chem 255:2472–2475, 1980
  4. Morrison AR, Nishikawa K, Needleman P: Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney. Nature 267:259–260, 1977 | Article | PubMed | ChemPort |
  5. Dunn MJ, Hood VL: Prostaglandins and the kidney. Am J Physiol 233:F169–F184, 1977 | ChemPort |
  6. Dunn MJ, Liard JF, Dray F: Basal and stimulated rates of renal secretion and excretion of prostaglandins E2, Falpha, and 13, 14-dihydro-15-keto Falpha in the dog. Kidney Int 13:136–143, 1978
  7. McGiff JC, Crowshaw K, Terragno NA, Lonigro AJ: Release of prostaglandin-like substance into renal venous blood in response to angiotensin II. Circ Res 26-27:I-121–I-130, 1970
  8. McGiff JC, Terragno NA, Malik KU, Lonigro AJ: Release of a prostaglandin E-like substance from canine kidney by bradykinin. Circ Res 31:36–43, 1972 | PubMed | ChemPort |
  9. Zambraski EJ, Dunn MJ: Renal prostaglandin E2 secretion and excretion in conscious dogs. Am J Physiol 236:F552–F558, 1979
  10. Hassid A, Konieczkowski M, Dunn MJ: Prostaglandin synthesis in isolated rat kidney glomeruli. Proc Natl Acad Sci USA 76:1155–1159, 1979 | PubMed | ChemPort |
  11. Folkert VW, Schlondorff D: Prostaglandin synthesis in isolated glomeruli. Prostaglandins 17:79–86, 1979 | Article | PubMed | ISI | ChemPort |
  12. Terragno NA, Terragno A, Early JA, Roberts MA, McGiff JC: Endogenous prostaglandin synthesis inhibitor in the renal cortex: Effects on production of prostacyclin by renal blood vessels. Clin Sci Mol Med Suppl 55:199s–202s, 1978
  13. Bohman SO: Demonstration of prostaglandin synthesis in collecting duct cells and other types of the rabbit renal medulla. Prostaglandins 14:729–744, 1977
  14. Grenier FC, Smith WL: Formation of 6-keto-PGFlalpha by collecting tubule cells isolated from rabbit renal papillae. Prostaglandins 16:759–772, 1978
  15. Dunn MJ, Staley RS, Harrison M: Characterization of prostaglandin production in tissue culture of rat renal medullary cells. Prostaglandins 12:37–49, 1976
  16. Zusman RM, Keiser HR: Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. J Biol Chem 252:2069–2071, 1977
  17. Frolich JC, Wilson TW, Sweetman BJ, Smigel M, Nies AS, Carr K, Watson JT, Oates JA: Urinary prostaglandins: Identification and origin. J Clin Invest 55:763–770, 1975 | PubMed | ISI | ChemPort |
  18. Frolich JC, Williams WM, Sweetman BJ, Smigel M, Carr K, Hollifield JW, Fleisher S, Nies AS, Frisk-Homberg, M, Oates JA: Analysis of renal prostaglandin synthesis by competitive protein binding assay and gas chromatography-mass spectroscopy, in Advances in Prostaglandin and Thromboxane Research, edited by Samuels-son B, Paoletti R, New York, Raven Press, 1976, vol. 1, pp. 65–80
  19. Zusman RM, Keiser HR: Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Stimulation by vasoactive peptides. J Clin Invest 60:215–223, 1977 | PubMed | ChemPort |
  20. Walker L, Whorton A, Smigel M, France R, Frolich JC: Antidiuretic hormone increases renal prostaglandin synthesis in vivo. Am J Physiol 235:F180–F185, 1978
  21. Dunn MJ, Greely HP, Valtin H, Kinter LB, Beeuwkes R: Renal excretion of prostaglandin E2 and F2alpha in diabetes insipidus rats. Am J Physiol 235:E624–E627, 1978
  22. McGiff JC, Crowshaw K, Terragno NA, Lonigro AJ, Strand JC, Williamson MA, Lee JB, Ng KKF: Prosta-glandin-like substances appearing in canine renal venous blood during renal ischemia. Circ Res 27:765–782, 1970 | PubMed | ChemPort |
  23. Morrison AR, Nishikawa K, Needleman P: Thromboxane A2 biosynthesis in the ureter obstructed isolated perfused kidney of the rabbit. J Pharmacol Exp Ther 205:1–8, 1978
  24. Zipser RD, Hoefs JC, Speckart PF, Zia PK, Horton R: Prostaglandins: Modulators of renal function and pressor resistance in chronic liver disease. J Clin Endo Metahol 48:895–900, 1979
  25. Benabe JE, Klahr S, Morrison AR: Thromboxane A2 production in glycerol-induced acute renal failure (ARF). Clin Res 27:409A, 1979
  26. Dunn MJ: Renal prostaglandin synthesis in the spontaneously hypertensive rat. J Clin Invest 58:862–870, 1976
  27. McGiff JC, Crowshaw K, Terragno NA, Malik KU, Lonigro AJ: Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance. Clin Sci 42:223–233, 1972 | PubMed | ChemPort |
  28. Needleman P, Douglas JR, Jakschik G, Stoechlein PB, Johnson EM: Release of renal prostaglandins by catecholamines: Relationship to renal endocrine function. J Pharmacol Exp Ther 188:453–460, 1974
  29. Zenser TV, Davis BB: Effects of calcium on prostaglandin E2 synthesis by rat inner medullary slices. Am J Physiol 235:F213–F218, 1978
  30. Scherer B, Weber PC: Time-dependent changes in prostaglandin excretion in response to frusemide in man. Clin Sci 56:77–81, 1979
  31. Henrich WL, Anderson RJ, Berns AS, McDonald KM, Paulsen PJ, Berl T, Schrier RW: The role of renal nerves and prostaglandins in control of renal hemodynamics and plasma renin activity during hypotensive hemorrhage in the dog. J Clin Invest 61:744–750, 1978 | PubMed | ISI | ChemPort |
  32. Morrison AR, Moritz H, Needleman P: Mechanism of enhanced renal prostaglandin biosynthesis in ureter obstruction. J Biol Chem 253:8210–8212, 1978 | PubMed | ISI | ChemPort |
  33. Dunn MJ, Kinter LB, Shier D, Beeuwkes R: The interactions of vasopressin and renal prostaglandins in the homozygous diabetes insipidus rat. Clin Res 27:496A, 1979
  34. Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 231:232–235, 1971 | PubMed | ChemPort |
  35. Flower RJ, Vane JR: Some pharmacologic and biochemical aspects of prostaglandin biosynthesis and its inhibitors, in Prostaglandin Synthetase Inhibitors Their Effects on Physiological Functions and Pathological States, edited by Robinson HJ, Vane JR, New York, Raven Press, 1974, pp. 9–18
  36. Roth GJ, Stanford N, Majerus PN: Acetylation of prostaglandin synthetase by aspirin. Proc Nat Acad Sci USA 72:3073–3076, 1975
  37. Hamberg M: Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Comm 49:720–726, 1972
  38. Hansen HS: 15-Hydroxyprostaglandin dehydrogenase: A review. Prostaglandins 12:647–679, 1976 | Article | PubMed | ISI | ChemPort |
  39. Stone KJ, Hart M: Prostaglandin E2-9-ketoreductase in rabbit kidney. Prostaglandins 10:273–288, 1975 | Article | PubMed | ChemPort |
  40. Kaplan L, Weiss J, Elsbach P: Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes. Proc Natl Acad Sci USA 75:2955–2958, 1978
  41. Rennick BR: Renal tubular transport of prostaglandins: Inhibition by probenecid and indomethacin. Am J Physiol 233:F133–F137, 1977
  42. Newcombe DS, Thanassi NM, Ciosek CP Jr: Cartilage cyclic nucleotide phosphodieterase: Inhibition by anti-inflammatory agents. Life Sci 14:505–519, 1974 | Article | PubMed | ChemPort |
  43. Ciosek CP, Fahey JV, Ishikawa Y, Newcombe DS: PGE1-mediated cyclic AMP refactoriness: effects of cy-clohexamide and indomethacin. J Cyclic Nucleotide Res 1:229–235, 1975
  44. Kantor HS, Hampton M: Indomethacin in sub-micromolar concentrations inhibits cyclic AMP-dependent protein kinase. Nature 276:841–842, 1978 | Article | PubMed | ISI | ChemPort |
  45. Feldman D, Couropmitree C: Intrinsic mineral-ocorticoid agonist activity of some nonsteroidal anti-inflammatory drugs: A postulated mechanism for sodium retention. J Clin Invest 57:1–7, 1976
  46. Simpson RV, Goodfriend TL: effects of inhibitors of prostaglandin synthesis on angiotensin responses and receptors. Fed Proc 36:677, 1979
  47. Northover BJ: Indomethacin-A calcium antagonist. Gen Pharmac 8:293–296, 1977
  48. Swain JA, Heyndrickx GR, Boettcher DH, Vatner SF: Prostaglandin control of renal circulation in the un-anesthetized dog and baboon. Am J Physiol 229:826–830, 1975
  49. Terragno NA, Terragno DA, McGiff JC: Contribution of prostaglandins to the renal circulation in conscious, anesthetized and laparotomized dogs. Circ Res 40:590–595, 1977
  50. Itskovitz HD, Stemper J, Pacholczyk D, McGiff JC: Renal prostaglandins: Determinants of intrarenal distribution of blood flow in the dog. Clin Sci Mol Med 45:321s–324s, 1973
  51. Lonigro AJ, Itskovitz HD, Crowshaw K, McGiff JC: Dependency of renal blood flow on prostaglandin synthesis in the dog. Circ Res 32:712–717, 1973
  52. Venuto RC, O'Dorisio T, Ferris TF, Stein JH: Prostaglandins and renal function: II. The effect of prostaglandin inhibition on autoregulation of blood flow in the intact kidney of the dog. Prostaglandins 9:817–828, 1975
  53. Feigen LP, Klainer E, Chapnick BM, Kadowitz PJ: The effect of indomethacin on renal function in pentobarbital-anesthetized dogs. J Pharmacol Exp Ther 198:457–463, 1976
  54. Noordewier B, Stygles VG, Hook JB, Gussin RZ: Effect of tolmetin on renal function and prostaglandin metabolism. J Pharmacol Exp Ther 204:461–468, 1978
  55. Nowak J, Wennmalm A: Influence of indomethacin and of prostaglandin E1 on total and regional blood flow in man. Acta Physiol Scand 102:484–491, 1978
  56. Herbaczynska-Cedro K, Vane JR: Prostaglandins as mediators of reactive hyperaemia in kidney. Nature 247:492, 1974 | Article |
  57. Spielman WS, Osswald H: Characterization of the post-occlusive response of renal blood flow in the cat. Am J Physiol 235:F286–F290, 1978
  58. Aizawa C, Honda N: Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits. Am J Physiol 233:F89–F93, 1977
  59. Anderson RJ, Sadi Taher M, Cronin RE, McDonald KM, Schrier RW: Effect of beta-adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. Am J Physiol 229:731–736, 1975 | PubMed | ISI | ChemPort |
  60. Finn WF, Arendshorst WJ: Effect of prostaglandin synthetase inhibitors on renal blood flow in the rat. Am J Physiol 231:1541–1545, 1976
  61. Blasingham C, Nasjletti A: Effects of prostaglandin synthesis inhibition on the renal actions of bradykinin in the dog. Physiologist 20:10, 1977
  62. Zimmerman B, Mommsen C, Kraft E: Interrelationship between renal prostaglandin (PG) E, renin and vascular tone in conscious dogs. Proc 4th Int Prostaglandin Conf, 1979, abst P129
  63. Aiken JW, Vane JR: Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Therap 184:678–687, 1973
  64. Satoh S, Zimmerman BG: Influence of the renin-angiotensin system on the effect of renal vasculature. Circ Res 36/37 (suppl l):89–96, 1975
  65. Chapnik BM, Paustian PW, Feigen LP, Joiner PD, Hyman AL, Kadowitz PJ: Influence of inhibitors of prostaglandin synthesis on renal vascular resistance and on renal vascular responses to vasopressor and vasodilator agents in the cat. Circ Res 40:348–354, 1977
  66. Carlson DE, Schramm LP: Humoral and mechanical factors modulating neural input to the renal vasculature. Am J Physiol 235:R64–R75, 1978
  67. Vatner SF: Effects of hemorrhage on regional blood flow distribution in dogs and primates. J Clin Invest 54:225–235, 1974
  68. Henrich WL, Anderson RJ, Berns AS, McDonald KM, Paulsen PJ, Berl PJ, Schrier RW: The role of renal nerves and prostaglandins in control of renal hemodynamics and plasma renin activity during hypotensive hemorrhage in the dog. J Clin Invest 61:744–750, 1978 | PubMed | ISI | ChemPort |
  69. Baylis C, Deen WM, Myers BD, Brenner BM: Effects of some vasodilator drugs on transcapillary fluid exchange in renal cortex. Am J Physiol 230:1148–1158, 1976 | PubMed | ISI | ChemPort |
  70. Baylis C, Brenner BM: Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat. Circ Res 43:889–898, 1978
  71. Ichikawa I, Brenner BM: Local intrarenal vasoconstrictor-vasodilator interactions in mild partial ureteral obstruction. Am J Physiol 236:F131–F140, 1979 | PubMed | ISI | ChemPort |
  72. Oken DE: Local mechanisms in the pathogenesis of acute renal failure. Kidney Int 10:S-94–99, 1976
  73. Torres VE, Strong CG, Romero JC, Wilson DM: Indomethacin enhancement of glycerol-induced acute renal failure in rabbits. Kidney Int 7:170–178, 1975
  74. Donker AJM, Arisz L, Brentjens JRH, van der Hem GK, Hollemans HJG: The effect of indomethacin on kidney function and plasma renin activity in man. Nephron 17:288–296, 1976 | PubMed | ChemPort |
  75. Vinci JM, Gill JR, Bowden RE, Pisano JJ, Izzo JL, Radfar N, Taylor AA, Zusman RM, Bartter FC, Keiser HR: The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition. J Clin Invest 61:1671–1682, 1978
  76. Arisz L, Donker AJM, Brentjens JRH, van der Hem GK: The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome. Acta Med Scand 199:121–125, 1976 | PubMed | ISI | ChemPort |
  77. Walshe JJ, Venuto RC: Acute oliguric renal failure induced by indomethacin: possible mechanism. Ann Intern Med 91:47–49, 1979
  78. Friedman WF, Hirschklau MJ, Printz MP, Pitlick PT, Kirkpatrick SE: Pharmacologic closure of patent ductus arteriosus in the premature infant. N Engl J Med 295:526–529, 1976 | PubMed | ISI | ChemPort |
  79. Heymann MA, Rudolph AM, Silverman NH: Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 295:530–533, 1976 | PubMed | ISI | ChemPort |
  80. Merrit TA, Disessa TG, Feldman BH, Kirkpatrick SE, Gluck L, Friedman WF: Closure of the patent ductus arteriosus with ligation and indomethacin: A consecutive experience. J Pediatr 93:639–646, 1978
  81. New Zealand Rheumatism Association Study: Aspirin and the kidney. Br Med J 1:593–596, 1974
  82. Burry HC, Dieppe PA, Bresnihan FB, Brown C: Silicy-lates and renal function in rheumatoid arthritis. Br Med J 1:613–615, 1976 | PubMed | ChemPort |
  83. Berg KJ, Bergan A: Effects of different doses of acetyl-salicyclic acid on renal function in the dog. Scan J Clin Lab Invest 36:779–794, 1976
  84. Berg KJ: Acute effects of acetylsalicyclic acid on renal function in normal man. Eur J Clin Pharmacol 11:117–123, 1977
  85. Berg KJ: Acute effects of acetylsalicyclic acid in patients with chronic renal insufficiency. Eur J Clin Pharmacol 11:111–116, 1977
  86. Kimberly RP, Plotz PH: Aspirin-induced depression of renal function. N Engl J Med 296:418–424, 1977
  87. Kimberly RP, Gill JR, Bowden RE, Keiser HR, Plotz PH: Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann Intern Med 89:336–341, 1978
  88. Kimberly RP, Bowden RE, Keiser HR, Plotz PH: Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med 64:804–807, 1978
  89. Bolger PM, Eisner GM, Ramwell PW, Slotkoff LM: Effect of prostaglandin synthesis on renal function and renin in the dog. Nature 259:244–245, 1976 | Article | PubMed | ChemPort |
  90. Larsson C, Weber P, Änggård E: Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit. Eur J Pharmacol 28:391–394, 1974 | PubMed |
  91. Weber P, Holzgreve H, Stephan R, Herbst R: Plasma renin activity and renal sodium and water excretion following infusion of arachidonic acid in rats. Eur J Pharmacol 34:299–304, 1975
  92. Weber PC, Larsson C, Änggård C, Hamberg M, Corey EJ, Nicolou KC, Samuelsson B: Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circ Res 39:868–874, 1976
  93. Whorton AR, Misono K, Hollifield J, Frolich JC, Ingami T, Oates JA: Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2. Prostaglandins 14:1095–1104, 1977 | PubMed |
  94. Gerber JG, Branch RA, Nies AS, Gerkens JF, Shand DG, Hollifield J, Oates JA: Prostaglandins and renin release: II. Assessment of renin secretion following infusion of PGI2, E2 and D2 into the renal artery of anesthetized dogs. Prostaglandins 15:81–88, 1978
  95. Yun J, Kelly G, Bartter FC, Smith H: Role of prostaglandins in the control of renin secretion in the dog. Circ Res 40:459–464, 1977 | PubMed | ChemPort |
  96. Yun JCH, Kelly GD, Bartter FC, Smith GW: Role of prostaglandins in the control of renin secretion in the dog (II). Life Sci 23:945–952, 1978
  97. Data JL, Gerber JG, Crump WJ, Frölich JC, Hollifield JW, Nies AS: The prostaglandin system-A role in canine baroreceptor control of renin release. Circ Res 42:454–458, 1978
  98. Seymour AA, Zehr JE: Influence of renal prostaglandin synthesis on renin control mechanisms in the dog. Circ Res 45:13–25, 1979
  99. Rumpf KW, Frenzel S, Lowitz HD, Scheler F: The effect of indomethacin on plasma renin activity in man under normal conditions and after stimulation of the renin angiotensin system. Prostaglandins 10:641–648, 1975 | PubMed |
  100. Patak RV, Mookerjee BK, Bentzel CJ, Hysert PE, Babeu M, Lee JB: Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. Prostaglandins 10:649–659, 1975
  101. Frölich JC, Hollifield JW, Dormois JC, Seyberth HJ, Michelakis AM, Oates JA: Suppression of plasma renin activity by indomethacin in man. Circ Res 39:447–452, 1976 | PubMed |
  102. Speckart P, Zia P, Zipser R, Horton R: The effect of sodium restriction and prostaglandin inhibition on the renin-angiotensin system in man. J Clin Endocrinol Metab 44:832–837, 1977
  103. Weber PC, Scherer B, Larsson C: Increase of free arachidonic acid by furosemide in man as the cause of prostaglandin and renin release. Eur J Pharmacol 41:329–332, 1977
  104. Tan SY, Mulrow PJ: Inhibition of the renin-aldosterone response to furosemide by indomethacin. J Clin Endocrinol Metab 45:174–176, 1977
  105. Noordewier B, Bailie MD, Hook JB: Effects of indomethacin and tolmetin on furosemide-induced changes in renin release. Proc Soc Exp Biol Med 159:180–183, 1978
  106. Berl T, Henrich WL, Erickson AL, Schrier RW: Prostaglandins in the beta-adrenergic and baroreceptor-mediated secretion of renin. Am J Physiol 236:F472–F477, 1979 | PubMed |
  107. Campbell WB, Graham RM, Jackson EK: Role of renal prostaglandins in sympathetically mediated renin release in the rat. J Clin Invest 64:448–456, 1979
  108. Frölich JC, Hollifield JW, Michelakis AM, Vesper BS, Wilson JP, Shand DG, Seyberth HJ, Frölich WH, Oates JA: Reduction of plasma renin activity by inhibition of the fatty acid cyclo-oxygenase in human subjects: Independence of sodium retention. Circ Res 44:781–787, 1979 | PubMed |
  109. Fichman MP, Telfer N, Zia P, Speckart P, Golub M, Rude R: Role of prostaglandins in the pathogenesis of Bartter's syndrome. Am J Med 60:785–797, 1976 | Article | PubMed | ChemPort |
  110. Gill JR, Frölich JC, Bowden RE, Taylor AA, Keiser HR, Seyberth HW, Oates JA, Bartter FC: Bartter's syndrome: A disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis. Am J Med 61:43–51, 1976 | Article | PubMed | ISI |
  111. Halushka PV, Wohltmann H, Privitera PJ, Hurwitz G, Margolius HS: Bartter's syndrome: Urinary prostaglandin E-like material and kallikrein; indomethacin effects. Ann Intern Med 87:281–286, 1977
  112. Donker AJM, deJong PE, Statius van Eps LW, Brentjens JRH, Bakker K, Doorenbos H: Indomethacin in Bartter's syndrome. Nephron 19:200–213, 1977
  113. Bowden RE, Gill JR, Radfay N, Taylor AA, Keiser HR: Prostaglandin synthetase inhibitors in Bartter's syndrome: Effect on immunoreactive prostaglandin excretion. JAMA 239:117–121, 1978
  114. Gill JR, Bartter FC: Evidence for a prostaglandin-independent defect in chloride reabsorption in the Loop of Henle as a proximal cause of Bartter's syndrome. Am J Med 65:766–772, 1978 | Article | PubMed | ISI | ChemPort |
  115. Galvez OG, Bay WH, Roberts BW, Ferris TF: The hemodynamic effects of potassium deficiency in the dog. Circ Res 40(suppl. 1): 11–16, 1977
  116. Hood V, Dunn M: Urinary excretion of prostaglandin E2 and F2alpha in potassium deficient rats. Prostaglandin 15:273–280, 1978
  117. Norby LH, Weidig J, Ramwell P, Slotkoff L, Flamenbaum W: Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoal-dosteronism. Lancet 1118–1121, 1978
  118. Tan SY, Shapiro R, Franco R, Stockard H, Mulrow PJ: Indomethacin-induced prostaglandin inhibition with hyperkalemia. Ann Intern Med 90:783–785, 1979
  119. Anderson RJ, Berl T, McDonald KM, Schrier RW: Prostaglandins: Effects on blood pressure, renal blood flow, sodium, and water excretion. Kidney Int 10:205–215, 1976 | PubMed | ISI | ChemPort |
  120. Iino Y, Imai M: Effects of prostaglandins on NA transport in isolated collecting tubules. Pfluegers Arch 373:125–132, 1978
  121. Stokes JB, Kokko JP: Inhibition of sodium transport by prostaglandin E2 acorss the isolated, perfused rabbit collecting tubule. J Clin Invest 59:1099–1104, 1977 | PubMed | ISI | ChemPort |
  122. Ganguli M, Tobian L, Azar S, O'Donnell M: Evidence that prostaglandin synthesis inhibitors increase the concentration of sodium and chloride in rat renal medulla. Circ Res 40(suppl. 1):135–139, 1977
  123. Feldman D, Loose DS, Tan SY: Nonsteroidal anti-inflammatory drugs cause sodium and water retention in the rat. Am J Physiol 234:F490–F496, 1978
  124. Altsheler P, Klahr S, Rosenbaum R, Slatopolsky E: Effects of inhibitors of prostaglandin synthesis on renal sodium excretion in normal dogs and dogs with decreased renal mass. Am J Physiol 235:F338–F344, 1978
  125. Roman RJ, Kauker ML: Renal effect of prostaglandin synthetase inhibition in rats: micropuncture studies. Am J Physiol 235:F111–F118, 1978
  126. Epstein M, Lifschitz MD, Hoffman DS, Stein JH: Relationship between renal prostaglandin E and renal sodium handling during water immersion in normal man. Circ Res 45:71–80, 1979
  127. Bailie MD, Crosslan K, Hook JB: Natriuretic effect of furosemide after inhibition of prostaglandin synthetase. J Pharmacol Exp Ther 199:469–476, 1976
  128. Oliw E, Köver G, Larsson C, Änggård E: Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit. Eur J Pharmacol 49:381–388, 1978
  129. Anderson RJ, Berl T, McDonald KM, Schrier RW: Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney. J Clin Invest 56:420–426, 1975 | PubMed | ChemPort |
  130. Berl T, Raz A, Wald H, Horowitz J, Czaczkes W: Prostaglandin synthesis inhibition and the action of vasopressin: Studies in man and rat. Am J Physiol 232:F529–F537, 1977
  131. Abe K, Yasujima M, Chiba S, Irokawa N, Ito T, Yoshinaga K: Effect of furosemide on urinary excretion of prostaglandin E in normal volunteers and patients with essential hypertension. Prostaglandins 14:513–521, 1977
  132. Scherer B, Schnermann J, Sofroniev M, Weber PC: Prostaglandin (PG) analysis in urine of humans and rats by different radioimmunoassays: Effect on PG-excretion by PG-synthetase inhibitors, laparotomy and furosemide. Prostaglandins 15:255–266, 1978
  133. Scherer B, Weber PC: Time dependent changes in prostaglandin excretion in response to frusemide in man. Clin Sci 56:77–81, 1979
  134. Oliw E, Änggård E: Different effects of furosemide on urinary excretion of prostaglandin E2 and F2alpha in rabbits. Acta Physiol Scand 105:367–373, 1979
  135. Oliw E, Köver G, Larsson C, Änggård E: Reduction by indomethacin of furosemide effects in the rabbit. Eur J Pharmacol 38:95–100, 1976
  136. Tiggeler RGWL, Koene RAP, Wudeveld PGAB: Inhibition of frusemide-induced natriuresis by indomethacin in patients with the nephrotic syndrome. Clin Sci Mol Med 52:149–151, 1977
  137. Köver G, Tost H: The effect of indomethacin on kidney function: indomethacin and furosemide antagonism. Pfluegers Arch 372:215–220, 1977
  138. Data JL, Rane A, Gerkens J, Wilkinson GR, Nies AS, Branch RA: The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog. J Pharmacol Ther 206:431–438, 1978
  139. Scriabine A, Watson LS, Russon HF, Ludden CT, Sweet CS, Fanelli GM, Bohidar NR, Stone A: Diuretic and antihypertensive effects of 2-aminoethyl-4-(l,l-di-methylethy)-6-iodophenol hydrochloride (MK-447). J Pharmacol Exp Ther 208:148–154, 1978
  140. Olsen UB: The pharmacology of bumetanide: A review. Acta Pharmacol Toxicol 41 (suppl. 3):1–29, 1977
  141. Durao V, Prata MM, Goncalves LM: Modification of antihypertensive effect of beta-adrenoceptor-blocking agents by inhibition of endogenous prostaglandin synthesis. Lancet 2:1005–1007, 1977
  142. Lopez-Ovejero JA, Weber MA, Drayer JIM, Sealey JE, Laragh JH: Effects of indomethacin alone and during diuretic or beta-adrenoreceptor-blockade therapy on blood pressure and the renin system in essential hypertension. Clin Sci Mol Med Suppl 203s–205s, 1978

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