Symposium on Urolithiasis

Kidney International (1978) 13, 361–371; doi:10.1038/ki.1978.54

Inhibitors and promoters of stone formation

Herbert Fleisch1

1Department of Pathophysiology, University of Berne, Berne, Switzerland

Correspondence: Prof H Fleisch, Department of Pathophysiology, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland.

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Abstract

Currently, three main mechanisms are thought to be important in the formation of urinary stones: 1) the relationship between the concentration of the precipitating substances in urine and the solubility of the mineral phase formed, 2) the role of promoters of crystallization and aggregation, and 3) the part played by inhibitors of crystal formation and aggregation (Fig. 1).

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