Symposium on Analgesic Nephropathy

Kidney International (1978) 13, 5–14; doi:10.1038/ki.1978.2

Experimental renal papillary necrosis

Elizabeth Ann Molland1

1Institute of Pathology, The London Hospital, Whitechapel, England

Correspondence: Dr E A Molland, Institute of Pathology, The London Hospital, Whitechapel, E.1.1BB, England.

Top

Abstract

A causal relationship between excessive intake of analgesics and renal damage is now widely accepted, but the identity of the analgesics involved and the pathogenesis of the lesion remain controversial.

Top

References

  1. Shelley JH: Phenacetin through the looking glass. Clin Pharmacol Ther 8:427–471, 1967
  2. Abel JA: Analgesic nephropathy: A review of the literature 1967–1970. Clin Pharmacol Ther 12:583–598, 1971
  3. Nanra RS, Kincaid-Smith P: Chronic effect of analgesics on the kidney. Progr Biochem Pharmacol 7:285–323, 1972
  4. Michielson P, De Schepper PJ (with the collaboration of De Broe M., Valkenborgh G. and Tricot J. P.): Renal diseases due to drugs, in Drug-Induced Diseases, edited by Meyler L and Peck HM, Amsterdam, Excerpta Medica, 1972 (vol. 4), pp. 261–314
  5. Gross M, Greenberg LA: The Salicylates: A Critical Biographical Review. New Haven, Connecticut, Hillhouse Press, 1948, pp. 99–101
  6. Fellers FX, Pradilla A, Craig JM: The enhancement of salicylate toxicity by Diamox: Chemical and morphological analysis, in Progress in Pyelonephritis, edited by Kass EH, Philadelphia, F. A. Davis Company, 1965, pp. 337–346
  7. Robinson MJ, Nichols EA, Taitz L: Nephrotoxic effect of acute sodium salicylate intoxication in the rat. Arch Pathol 84:224–226, 1967
  8. Calder I, Funder CC, Green CR, Ham KN, Tange JD: Comparative nephrotoxicity of aspirin and phenacetin derivatives. Br Med J 4:518–521, 1971
  9. Arnold L, Collins C, Starmer GA: The short-term effects of analgesics on the kidney with special reference to acetylsalicylic acid. Pathology 5:123–134, 1973
  10. Raab W: Analgetika und Renale Enzymausscheidung: Harnenzymaktiväten bei Ratten nach Verabreichung von hohen Dosen Acetylosalicylsäure. Clin Chim Acta 22:535–543, 1968
  11. Prescott LF: Some observations on the nephrotoxicity of analgesics other than phenacetin, in Renal Infection and Renal Scarring, edited by Kincaid-Smith P and Fairley KF, Melbourne, Mercedes, 1971, pp. 421–436
  12. Raab W: Acetylsalicylic acid and the kidneys. Helv Med Acta 34:498–502, 1969
  13. Plummer DT, Leathwood PD, Blake ME: Urinary enzymes and kidney damage by aspirin and phenacetin. Chem Biol Interact 10:277–284, 1975
  14. Berry HK, Guest GM: The effect of salicylate intoxication on amino-acid excretion in rats. Metabolism 12:760–770, 1963 | PubMed | ISI |
  15. Ramsay AG, Elliott HC: Effect of acetylsalicyclic acid on ionic reabsorption in the renal tubule. Am J Physiol 213:323–327, 1967
  16. Qintanilla A, Kessler RH: Direct effects of salicylate on renal function in the dog. J Clin Invest 52:3143–3153, 1973
  17. Calder IC, Funder CC, Green CR, Ham KN, Tange JD: Nephrotoxic lesions from 5-aminosalicylic acid. Br Med J 1:152–154, 1972
  18. Studer A, Zbinden G, Fust B: Weitere tierexperimentelle: Untersuchungen zur Frage Scherzmittelmissbrauch und interstitielle Nephritis. Schweiz Med Wochenschr 88:469–470, 1958
  19. Vivaldi E: Effect of chronic administration of analgesics on resistance to experimental infection of the urinary tract in rats. Nephron 5:202–209, 1968
  20. Eder H: Chronic toxicity studies on phenacetin, N-acetyl-paminophenol (NAPA) and acetylsalicylic acid on cats. Acta Pharmacol Toxicol 21:197–204, 1964
  21. Schnitzer B, Smith EB, Golden A. The effects of phenacetin and its contaminant on the kidney of the rat. Am J Pathol 917–924, 1965
  22. Peters G, Baechtold-Fowler N, Bonjour J, Chomety-Diezi F, Filloux B, Guidoux R, Guignard JP, Peters-Haefell L, Roch-Ramel F, Schelling JL, Hedinger C, Weber E: General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat. Arch Toxikol 28:225–269, 1972
  23. Woodard G, Post KF, Cockrell KD, Cronin MTI: Phenacetin: Long term studies in rats and dogs. Toxicol Appl Pharmacol 7:503, 1965
  24. Clausen E: Histological changes in rabbit kidneys induced by phenacetin and acetylsalicylic acid. Lancet 2:123–124, 1964
  25. Fordham CC, Huffines WD, Welt LG: Phenacetin-induced renal disease in rats. Ann Intern Med 62:738–743, 1965
  26. Abrahams C, Rubenstein AH, Levin NW, Wunderlich U. Experimentally induced analgesic nephritis in rats. Arch Pathol 78:222–230, 1964
  27. Abrahams C, Levin NW: Experimentally induced analgesic nephropathy. MedProc 13:506–514, 1967
  28. Saker BM, Kincaid-Smith P: Papillary necrosis in experimental analgesic nephropathy. Br Med J 1:161–162, 1969
  29. Goldberg M, Myers CL, Peshel W, McCarron D, Morrison AB: Mechanism of analgesic abuse nephropathy (abstr.). J Clin Invest 50:37a, 1971
  30. Nanra RS, Kincaid-Smith P: Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures. Br Med J 3:559–561, 1970
  31. Nanra RS, Chirawong P, Kincaid-Smith P: Renal papillary necrosis in rats produced by aspirin, A.P.C. and other analgesics, in Renal Infection and Renal Scarring, edited by Kincaid-Smith P and Fairley KF, Melbourne, Mercedes, 1971, pp. 347–358
  32. Axelsen RA: Analgesic-induced renal papillary necrosis in the Gunn rat: The comparative nephrotoxicity of aspirin and phenacetin. J Pathol 120:145–150, 1976
  33. Pytel YA: The pathogenesis of necrosis of renal papillae. Urologiya 32:3–9, 1967
  34. Leonards JR: Does aspirin cause analgesic nephropathy in rats? In Abstr V Int Congress Nephrol, edited by Villarreal H, Mexico City, Basel, New York, S Karger, 1972, p. 50
  35. McIver MA, Hobbs JB: The failure of high doses of aspirin to produce renal lesions in pigs. Med J Aust 1:197–199, 1975
  36. Nanra RS: Pathology, aetiology and pathogenesis of analgesic nephropathy. Aust NZ J Med 4:602–603, 1974
  37. Burry AF: The evolution of analgesic nephropathy. Nephron 5:185–201, 1967
  38. Brown DM, Hardy TL: Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney. Br J Pharmacol Chemother 32:17–24, 1968
  39. Arnold L, Collins C, Starmer GA: Renal and gastric lesions after phenylbutazone and indomethacin in the rat. Pathology 6:303–313, 1974
  40. Bokelman DL, Bagdon WJ, Mattis PA, Stonier PF: Strain-dependent renal toxicity of a non-steroid anti-inflammatory agent. Toxicol Appl Pharmacol 19:111–124, 1971
  41. Wiseman EH, Reinert H: Anti-inflammatory drugs and renal papillary necrosis. Agents Actions 5/4:322–325, 1975
  42. Kaump DH: Pharmacology of the fenemates 11 toxicology in animals. Ann Phys Med (suppl.) 9:16–23, 1966
  43. Hardy TL: N-phenyl anthranilic acid: An agent for inducing and studying renal papillary necrosis in the rat. Br J Exp Pathol 51:348–355, 1970
  44. Emmerson JL, Gibson WR, Pierce EC, Todd GC: Preclinical toxicology of fenoprofen. Toxicol Appl Pharmacol 25:444, 1973
  45. Boyd EM, Dolman M, Knight LM, Sheppard EP: The chronic oral toxicity of caffeine. Can J Physiol Pharmacol 43:995–1007, 1965
  46. Steele TW, Edwards KDG: Abnormalities of urinary concentrating, acidifying and sodium conserving abilities induced by excess analgesic intake in rats. Aust Ann Med 19:412–413, 1970
  47. Clausen E: Histologic changes in the kidneys caused by phenacetin and acetylsalicylic acid, animal experiments, in Progress in Pyelonephritis, edited by Kass EH, Philadelphia, FA. Davis Company, 1965, pp. 332–336
  48. Bluemle LW, Goldberg M: Renal accumulation of salicylate and phenacetin: Possible mechanisms in the nephropathy of analgesic abuse. J Clin Invest 47:2507–2514, 1968
  49. Kincaid-Smith P, Saker BM, McKenzie IFC, Muriden KD: Lesions in the blood supply of the papilla in experimental analgesic nephropathy. Med J Aust 1:203–206, 1968
  50. Abrahams C, Levinson C. Ultrastructure of the renal papilla in experimentally induced analgesic nephritis in rats. S Afr Med J 44:63–65, 1970
  51. Nanra RS, Chirawong P, Kincaid-Smith P: Medullary ischaemia in experimental analgesic nephropathy: The pathogenesis of renal papillary necrosis. Aust NZ J Med 3:580–583, 1973
  52. Ham KN, Tange JD: Some experimental observations relating to the pathogenesis of renal papillary necrosis. Aust Ann Med 18:199–206, 1969
  53. Molland EA: Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy. J Pathol 120:43–48, 1976
  54. McGiff JC, Crowshaw K, Itskovitz HD: Prostaglandins and renal function. Fed Proc 33:39–47, 1974
  55. Zins GR: Renal prostaglandins. Am J Med 58:14–24, 1975 | Article | PubMed | ChemPort |
  56. Itskovitz HD, Stemper J, Pacholczyk D, McGiff JC: Renal prostaglandins: Determinants of intrarenal distribution of blood flow in the dog. Clin Sci Mol Med 45:321s–324s, 1973
  57. Lonigro AJ, Itskovitz HD, Crowshaw K, McGiff JC: Dependency of renal blood flow on prostaglandin synthesis in the dog. Circ Res 32:712–717, 1973
  58. Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature [New Biol] 231:232–235, 1971 | ISI | ChemPort |
  59. Flower RJ, Gryglewski R, Herbaczynska-Cedro K, Vane JR: Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature [New Biol] 238:104–106, 1972 | ChemPort |
  60. Gault MH: Demonstration of an intrarenal gradient for 14 C-acetyl-salicylic acid (ASA) in rabbits and guinea pigs. Abst IV Annu Meeting Am Soc Nephrol 28:1970
  61. Nissen HM, Bojesen I: On lipid droplets in renal interstitial cells: IV. Isolation and indentification. Z Zellforsch 97:274–284, 1969
  62. Muirhead EE, Germain GS, Leach BE, Pitcock JA, Stephenson P, Brooks B, Brosino WL, Daniels EG, Hinman JW: Production of renomedullary prostaglandins by renomedullary interstitial cells grown in tissue culture. Circ Res 30–31 (suppl. 11):161–172, 1972
  63. Molland EA: Studies on the pathogenesis of aspirin nephrotoxicity in the rat. Dissertation for degree of M.D., University of Cambridge
  64. Farber SJ, Cohen GL, Kastor JA: The chemical and metabolic properties of acid mucopolysaccharides of renal papillae. Trans Assoc Am Physicians 75:154–159, 1962
  65. Wheldrake JF: The effect of aspirin (acetyl salicylate) on macromolecule turnover in the rat kidney and liver. Experientia 31:559–560, 1975
  66. Pinter GG: A possible role of acid mucopolysaccharides in the urine concentrating process. Experientia 23:100–101, 1967
  67. Hardy TL: Partial papillectomy and the study of drug-induced renal papillary necrosis in the rat. Br J Exp Pathol 51:591–596, 1970
  68. Burry HC, Dieppe PA, Bresnihan FB, Brown C: Salicylates and renal function in rheumatoid arthritis. Br Med J 1:613–615, 1976 | PubMed | ChemPort |

Extra navigation

.
ADVERTISEMENT