Abstract
Objective:
Prior to therapeutic hypothermia (that is, cooling), transfontanellar duplex brain sonography resistive indices (RI) were studied as a bedside non-invasive measures of cerebral hemodynamics in neonates who suffered from hypoxic-ischemic encephalopathy (HIE). We compared pre- and post-cooling RI values and examined the relationships between RI values and specific long-term neurodevelopmental outcomes.
Study Design:
Transfontanellar duplex brain sonography, including RI, were obtained for 28 neonates prior to cooling and for 20 neonates following cooling. All RI values were sampled in the anterior cerebral artery at the beginning of each ultrasound study. Neurodevelopmental assessment was conducted between ages 20–32 months with the Mullen Scale of Early Learning. The relationships between pre- and post-cooling RI and cognitive and motor outcomes were studied.
Result:
Neonates with RI values <0.60 prior to and following cooling were more likely to die or have severe neurodevelopmental disability by ages 20–32 months than those with RI>0.60. Lower RI values were associated with specific neurodevelopmental deficits in motor skill attainment.
Conclusion:
Pre- and post-cooling transfontanellar duplex brain sonography RI values may be a useful prognostic tool, in conjunction with other clinical information, for neonates diagnosed with HIE. The results of this study suggest that further study of the prognostic value of RI values for short- and long-term outcomes is warranted.
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References
Kurinczuk JJ, White-Koning M, Badawi N . Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev 2010; 86: 329–338.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG . Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; 1: CD003311.
Gunn AJ, Wyatt JS, Whitelaw A, Barks J, Azzopardi D, Ballard R et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 2008; 152: 55–58, 58.e1.
Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361: 1349–1358.
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353: 1574–1584.
Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ 1998; 317: 1549–1553.
Marlow N, Rose AS, Rands CE, Draper ES . Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 2005; 90: F380–F387.
Robertson CM, Finer NN, Grace MG . School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr 1989; 114: 753–760.
Wintermark P, Hansen A, Gregas MC, Soul J, Labrecque M, Robertson RL et al. Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol 2011; 32: 2023–2029.
Greisen G . Autoregulation of cerebral blood flow in newborn babies. Early Hum Dev 2005; 81: 423–428.
Howlett JA, Northington FJ, Gilmore MM, Tekes A, Huisman TA, Parkinson C et al. Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy. Pediatr Res 2013; 74: 525–535.
Orman G, Benson JE, Kweldam CF, Bosemani T, Tekes A, de Jong MR et al. Neonatal head ultrasonography today: a powerful imaging tool!. J Neuroimaging 2015; 25: 31–55.
Ilves P, Lintrop M, Metsvaht T, Vaher U, Talvik T . Cerebral blood-flow velocities in predicting outcome of asphyxiated newborn infants. Acta Paediatr 2004; 93: 523–528.
Ilves P, Lintrop M, Talvik I, Muug K, Maipuu L . Changes in cerebral and visceral blood flow velocities in asphyxiated term neonates with hypoxic-ischemic encephalopathy. J Ultrasound Med 2009; 28: 1471–1480.
Perlman JM . The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage—a historical perspective. Semin Pediatr Neurol 2009; 16: 191–199.
Jongeling BR, Badawi N, Kurinczuk JJ, Thonell S, Watson L, Dixon G et al. Cranial ultrasound as a predictor of outcome in term newborn encephalopathy. Pediatr Neurol 2002; 26: 37–42.
Elstad M, Whitelaw A, Thoresen M . Cerebral Resistance Index is less predictive in hypothermic encephalopathic newborns. Acta Paediatr 2011; 100: 1344–1349.
Skranes JH, Elstad M, Thoresen M, Cowan FM, Stiris T, Fugelseth D . Hypothermia makes cerebral resistance index a poor prognostic tool in encephalopathic newborns. Neonatology 2014; 106: 17–23.
Ryan C, Barrington K, Vaughan D, Finer N . Directly measured arterial oxygen saturation in the newborn infant. J Pediatr 1986; 109: 526–529.
Sarnat HB, Sarnat MS . Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976; 33: 696–705.
Mullen EM . Mullen Scales of Early Learning. Pearson Clinical Assessments: San Antonio, TX, USA, 1995.
Russell D, Rosenbaum P, Avery L, Lane M . Gross Motor Function Measure (GMFM-66 and GMFM-88) User's Manual. Mac Keith Press: London, UK, 2002.
Levene MI, Evans DH, Forde A, Archer LN . Value of intracranial pressure monitoring of asphyxiated newborn infants. Dev Med Child Neurol 1987; 29: 311–319.
Eken P, Toet MC, Groenendaal F, de Vries LS . Predictive value of early neuroimaging, pulsed Doppler and neurophysiology in full term infants with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 1995; 73: F75–F80.
Low JA . Cerebral perfusion, metabolism, and outcome. Curr Opin Pediatr 1995; 7: 132–139.
Bulas DI . Transcranial doppler: applications in neonates and children. Ultrasound Clin 2009; 4: 533–551.
Kawakami M, Koda M, Murawaki Y, Kawasaki H, Ikawa S . Cerebral vascular resistance assessed by transcranial color Doppler ultrasonography in patients with chronic liver diseases. J Gastroenterol Hepatol 2001; 16: 890–897.
Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med 2014; 371: 140–149.
Acknowledgements
GJG was supported by NIH grant NICHD 5T32HD007414-18 during writing of this manuscript. VJB was supported by NIH grant NINDS K12-NS001696 during the writing of this manuscript. FJN was supported by NIH HD070995 during the writing of this manuscript.
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Gerner, G., Burton, V., Poretti, A. et al. Transfontanellar duplex brain ultrasonography resistive indices as a prognostic tool in neonatal hypoxic-ischemic encephalopathy before and after treatment with therapeutic hypothermia. J Perinatol 36, 202–206 (2016). https://doi.org/10.1038/jp.2015.169
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DOI: https://doi.org/10.1038/jp.2015.169
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