Abstract
Objective:
To examine the association between maternal 25-hydroxyvitamin D (25(OH)D) and adverse labor and delivery outcomes.
Study Design:
We measured serum 25(OH)D at ⩽26 weeks gestation in a random subsample of vertex, singleton pregnancies in women who labored (n=2798) from the 12-site Collaborative Perinatal Project (1959 to 1966). We used labor and delivery data to classify cases of adverse outcomes.
Result:
Twenty-four percent of women were vitamin D deficient (25(OH)D <30 nmol l−1), and 4.5, 3.3, 1.9 and 7.5% of women had prolonged stage 1 labor, prolonged stage 2 labor, primary cesarean delivery or indicated instrumental delivery, respectively. After adjustment for prepregnancy body mass index, race and study site, 25(OH)D concentrations were not associated with risk of prolonged stage 1 or 2, cesarean delivery or instrumental delivery.
Conclusion:
Maternal vitamin D status at ⩽26 weeks was not associated with risk of prolonged labor or operative delivery in an era with a low cesarean rate.
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Acknowledgements
This study was supported by NIH grant HD056999 (PI: BLM). We thank Jill Diesel for her assistance with data management. Dr Gernand’s research is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under BIRCWH award number K12HD055882, “Career Development Program in Women’s Health Research at Penn State.” The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Gernand, A., Klebanoff, M., Simhan, H. et al. Maternal vitamin D status, prolonged labor, cesarean delivery and instrumental delivery in an era with a low cesarean rate. J Perinatol 35, 23–28 (2015). https://doi.org/10.1038/jp.2014.139
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DOI: https://doi.org/10.1038/jp.2014.139
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