Original Article
Journal of Perinatology (2008) 28, 523–525; doi:10.1038/jp.2008.55; published online 3 July 2008
The effect of early and late umbilical cord clamping on neonatal hematocrit
A Jahazi1, M Kordi2, N B Mirbehbahani3 and S R Mazloom4
- 1Midwifery Department, Gorgan Branch, Islamic Azad University, Golestan, Iran
- 2Midwifery Department, Mashad College of Nursing-Midwifery, Khorasan Razavi, Iran
- 3Neonatology Department, Gorgan University of Medical Sciences, Golestan, Iran
- 4Midwifery Department, Mashad College of Nursing-Midwifery, Khorasan Razavi, Iran
Correspondence: A Jahazi, Midwifery Department, Islamic azad university, gorgan branch, Daneshgah, PO Box: 715, Gorgan, Golestan 98, Iran. E-mail: a_jahazi@yahoo.com
Received 22 May 2007; Revised 21 February 2008; Accepted 7 April 2008; Published online 3 July 2008.
Abstract
Objective:
To compare the effect of early and late cord clamping (LCC) on neonatal hematocrit at 2 and 18 h of life.
Study Design:
In this double-blind randomized trial, 64 healthy full-term vaginally born neonates were randomly allocated to either early (30 s) or late (3 min) umbilical cord clamping. During the interval between delivery and cord clamping, the attendant held the neonate supine at the level of the introitus. Neonatal venous hematocrit was measured at 2 and 18 h of life.
Result:
Neonatal hematocrit at 2 h of life (61
4.9 vs 61.64.5%) and 18 h of life (56.94.1 vs 56.23.9%) was not significantly different between the two groups. This was also true for neonatal polycythemia (20 vs 23.5%). In the LCC group, placental residual blood volume (PRBV) was 39.5% lower and estimated neonatal blood volume (ENBV) was 7.1% higher than that in the early cord clamping (ECC) group (P<0.001).
Conclusion:
Late cord clamping does not lead to a significant difference in the hematocrit level of the neonate or neonatal polycythemia, but is associated with a significant increase in ENBV and a significant decrease in PRBV. Further trials should examine the effect of delaying cord clamping for a longer period of time or changing the position that the neonate is held in to determine whether these variations result in more clinically significant results.
Keywords:
early cord clamping, late cord clamping, hematocrit, neonate, polycythemia
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RESEARCH
Journal of Perinatology Original Article
