Perinatal/Neonatal Case Presentation
Journal of Perinatology (2007) 27, 589–591. doi:10.1038/sj.jp.7211783
Currarino syndrome as an etiology of a neonatal Escherichia coli meningitis
J Fleury1, G Picherot1, C Cretolle2, G Podevin3, A David4, J Caillon5,6, J C Roze7 and C Gras-le Guen6,7
- 1Clinique Médicale Pédiatrique, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France
- 2Service de Chirurgie Viscérale Infantile et INSERM U781, Hôpital Necker-Enfants Malades, Paris, France
- 3Service de Chirurgie Infantile, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France
- 4Service de Génétique Médicale, CHU Nantes, France
- 5Laboratoire de Microbiologie, CHU Nantes, France
- 6UPRES EA 3826, Faculté de Médecine de Nantes, Nantes, France
- 7Service de Néonatologie, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France
Correspondence: Dr C Gras-le Guen, Néonatologie, Hôpital Mère Enfant CHU Nantes, 38 bd Jean Monnet, Cedex 1, Nantes 44093, France. E-mail: christele.grasleguen@chu-nantes.fr
Received 19 February 2007; Revised 23 April 2007; Accepted 24 April 2007.
Abstract
We report the case of a 29-day-old baby girl in whom Escherichia coli meningitis led to the diagnosis of Currarino syndrome (CS) (OMIM 176450), an autosomal-dominant genetic disorder associated with sacral agenesis, anorectal malformation, presacral masses and spinal cord malformations. Her condition improved with antibiotics and early surgical treatment. A familial study identified other genetically related individuals with similar symptoms.
Keywords:
neonate, anorectal malformation, bacterial meningitis, Currarino syndrome, HLXB9 gene
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