Original Article
Journal of Perinatology (2007) 27, 278–283. doi:10.1038/sj.jp.7211688; published online 15 March 2007
Outcome of infants from mothers with anti-SSA/Ro antibodies
M Motta1, C Rodriguez-Perez1, A Tincani2, A Lojacono3 and G Chirico1
- 1Department of Neonatology and NICU, Spedali Civili-Brescia, Italy
- 2Department of Rheumatology and Clinical Immunology, University of Brescia, Spedali Civili-Brescia, Italy
- 3Department of Obstetrics and Gynecology, Spedali Civili-Brescia, Italy
Correspondence: Dr M Motta, Neonatology and Neonatal Intensive Care, Spedali Civili – Brescia, Brescia 25123, Italy. E-mail: lvmott@tin.it
Received 2 June 2006; Revised 27 September 2006; Accepted 6 February 2007; Published online 15 March 2007.
Abstract
Objective:
To evaluate the incidence of electrocardiographic and laboratory abnormalities in neonates born from mothers with connective tissue disease and positive for anti-SSA/Ro antibodies.
Study Design:
Electrocardiogram, blood cell counts, liver and renal function tests prospectively obtained from 51 infants born from anti-SSA/Ro-positive mothers with connective tissue disease were compared with those obtained from 50 control infants born from mothers with anti-extractable nuclear antigen (ENA)-negative connective tissue disease. One infant with congenital complete heart block was excluded from analysis.
Results:
No infant showed sinus bradycardia. A first-degree atrioventricular block at birth was observed in five study group and no control group infants, P=0.023. Atrioventricular blocks spontaneously reverted or remained stable during the first year of life. Mean corrected QT value of infants born from anti-SSA/Ro-positive mothers was slightly prolonged as compared with the control group (0.404
0.03 s vs 0.3950.02 s; P=0.060).
Conclusions:
Infants exposed to anti-SSA/Ro antibodies had a significantly higher prevalence of first-degree atrioventricular block. At variance with previous studies, we observed a low frequency of hematologic abnormalities and no cases of hepatobiliary disease.
Keywords:
connective tissue disease, anti-extractable nuclear antigen antibodies, atrioventricular block
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