Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Catheter related bloodstream infection following PICC removal in preterm infants

Abstract

Objective:

Describe the incidence of catheter-related blood stream infection (CRBSI), following removal of peripherally inserted central venous catheters (PICC) in preterm infants.

Study Design:

A retrospective cohort study of infants <29 weeks gestational age with a PICC revealed 101 PICCs placed (2159 PICC days). Patients were hospitalized in a level III Neonatal Intensive Care Unit (NICU) between January 2002 and December 2003. χ2 analysis was performed.

Results:

One infection was detected after the removal of a PICC (1 per 202 days). Ten infants had a CRBSI attributed to a PICC (1 per 216 PICC days). CRBSI during indwelling PICC was associated with increased risk for sepsis evaluation after PICC removal (P<0.05).

Conclusions:

The incidence of CRBSI in the 48 h following PICC removal was not different than the incidence of CRBSI while a PICC was in-dwelling. There was no evidence from this study to support antibacterial prophylaxis before PICC removal.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Duerkson DR, Papineau N, Siemens J et al. Peripherally inserted central catheters for parenteral nutrition: A comparison with centrally inserted catheters. JPEN Mar-Apr 1999; 23 (2): 85–89.

    Article  Google Scholar 

  2. O’Grady NP, Alexander M, Dellinger EP et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control: MMWR 2002 vol. 51/ No. RR-10.

  3. Craft AP, Finer NN, Barrington KJ . Vancomycin for prophylaxis against sepsis in preterm neonates. Cochrane Library 2004 Issue 2:CD001971.

  4. Isaacs D . A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units. Arch Dis Child Fet Neo Ed 2003; 88 (2): F89–F93.

    Article  CAS  Google Scholar 

  5. El-Hassan NO, Stephens TP, Gigliotti F et al. Vancomycin usage in central venous catheters in a neonatal intensive care unit. Ped Infect Dis J 2004; 23 (3): 201–206.

    Article  Google Scholar 

  6. Harms K, Herting E, Kron M et al. Randomized controlled trial of amoxicillin prophylaxis for prevention of catheter related infections in newborn infants with central venous silicone elastomer catheters. J. Pediatr. October 1995; 127 (4): 615–619.

    Article  CAS  Google Scholar 

  7. Chock VL . Therapeutic techniques: peripherally inserted central catheters in neonates. Neoreviews 2004; 5 (2): e60–e62.

    Article  Google Scholar 

  8. Gonzalez BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V . Early markers of late-onset sepsis in premature neonates: clinical, hematological, and cytokine profile. J Perinat Med. 2003; 31 (1): 60–68.

    Article  Google Scholar 

  9. Mahieu LM, De Muynck OD, Ieven MM, De Dooy JJ, Goossens HJ, Van Reempts PJ . Risk factors for central vascular catheter-associated bloodstream infections among patients in a neonatal intensive care unit. J Hosp Infection 2001; 48: 108–116.

    Article  CAS  Google Scholar 

  10. Chathas MK, Paton JB, Fisher DE . Percutaneous central venous catheterization: three years’ experience in a neonatal intensive care unit. Am J Dis Child 1990; 144 (11): 1246–1250.

    Article  CAS  Google Scholar 

  11. Pawar M, Mehta Y, Kapoor P et al. Central venous catheter-related blood stream infections: ncidence, risk factors, outcome, and associated pathogens. J Cardiothorac Vasc Anesth. 2004; 18 (3): 304–308.

    Article  Google Scholar 

Download references

Acknowledgements

We Thank Terry Leet, PhD. for technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R W Brooker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brooker, R., Keenan, W. Catheter related bloodstream infection following PICC removal in preterm infants. J Perinatol 27, 171–174 (2007). https://doi.org/10.1038/sj.jp.7211655

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211655

Keywords

This article is cited by

Search

Quick links