Original Article
Journal of Perinatology (2007) 27, 77–81. doi:10.1038/sj.jp.7211639
Maternal serum adiponectin levels during human pregnancy
S Mazaki-Tovi1,3, H Kanety2,3, C Pariente2, R Hemi2, A Wiser1,3, E Schiff1,3 and E Sivan1,3
- 1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel
- 2Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel
- 3Sackler School of Medicine, Tel Aviv University, Tel Aviv, Tel-Hashomer, Israel
Correspondence: Dr E Sivan, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer 52621, Israel. E-mail: eyal.sivan@gmail.com
Received 7 June 2006; Revised 5 September 2006; Accepted 24 November 2006.
Abstract
Objective:
Pregnancy is a unique situation characterized by insulin resistance. The role of adiponectin, an insulin-sensitizing hormone, has not been completely clarified during pregnancy. The aim of this cross-sectional study was to evaluate adiponectin levels during pregnancy and postpartum.
Study design:
Adiponectin and leptin levels were tested in 80 pregnant women, 20 in each trimester (mean gestational age 10.5
1.9; 19.34.9; 39.30.8 weeks,) as well as 4 days postpartum.
Results:
Adiponectin levels during first (13.33.6 
g/ml), second (12.64.4 g/ml) and third trimester (11.23.7 g/ml) did not differ and were significantly higher than postpartum levels (8.82.1 g/ml; P<0.0001, P<0.004 and P<0.02, respectively).
Conclusion:
Despite increased insulin resistance during pregnancy, no significant alterations in adiponectin levels were observed. This may imply that the regulation of adiponectin during gestation is altered. The elevated gestational adiponectin levels are consistent with increased 'adiponectin resistance' during pregnancy.
Keywords:
adiponectin, leptin, pregnancy, postpartum
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
RESEARCH
Serum Levels of the Adipokine Adipocyte Fatty Acid?binding Protein Are Increased in Preeclampsia
American Journal of Hypertension Original Article
Serum Levels of the Adipokine Adipocyte Fatty Acid?binding Protein Are Increased in Preeclampsia
American Journal of Hypertension Original Article
