Original Article
Journal of Perinatology (2006) 26, 130–133. doi:10.1038/sj.jp.7211433; published online 1 December 2005
Developmental outcome of very low birth weight twins conceived by assisted reproduction techniques
A Ito1, Y Honma1, E Inamori1, Y Yada1, M Y Momoi1 and Y Nakamura2
- 1Department of Pediatrics, Jichi Medical School, Kawachigun, Tochigi, Japan
- 2Department of Public Health, Jichi Medical School, Kawachigun, Tochigi, Japan
Correspondence: Dr Y Honma, Department of Pediatrics, Jichi Medical School, 3311-1, Yakushiji, Minami-kawachi-machi, Kawachigun, Tochigi, Japan. E-mail: yokohoma@jichi.ac.jp
Received 25 July 2005; Revised 7 November 2005; Accepted 9 November 2005; Published online 1 December 2005.
Abstract
Objective:
To evaluate the differences in developmental outcomes between very low birth weight twins conceived by assisted reproduction techniques and those conceived spontaneously.
Study design:
Twenty-two sets of very low birth weight twins were evaluated by the Kyoto Scale for Psychological Development at 36 months of corrected age. Total developmental quotient and developmental quotient (DQ) for three subscales, posture-motor, cognition-adaptation and language-social, were evaluated.
Results:
Twins conceived with medical assistance demonstrated a higher incidence of total DQ below 85 with lower DQ for cognition-adaptation and language-social skills than spontaneously conceived twins, whereas the quotient for posture-motor skills in medically assisted twins was comparable to that of spontaneously conceived twins.
Conclusion:
At 3 years of age very low birth weight twins conceived by assisted reproduction techniques demonstrated lower cognitive and language skills than twins conceived naturally.
Keywords:
VLBW, twin, cognition, language, assisted conception
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