Original Article
Journal of Perinatology (2006) 26, 115–119. doi:10.1038/sj.jp.7211422; published online 12 January 2006
Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection
T W Orlikowsky1, C Trüg1,2, F Neunhoeffer1, M Deperschmidt3, M Eichner4 and C F Poets1
- 1Department of Neonatology, University Children's Hospital, Tübingen, Germany
- 2Department of Surgery, Loretto Hospital, Freiburg, Germany
- 3University Women's Hospital, Tübingen, Germany
- 4Department of Medical Biometry, Tübingen, Germany
Correspondence: Dr CF Poets, Univ.-Kinderklinik Tübingen, Germany, Calwerstr. 7, 72076 Tübingen, Germany. E-mail:cfpoets@med.uni-tuebingen.de
Received 11 April 2005; Revised 11 April 2005; Accepted 21 October 2005; Published online 12 January 2006.
Abstract
Objectives:
To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI).
Study design:
A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined.
Results:
LBP in the noninfected group increased until 24 h after birth (P<0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r=0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24–68) and 79% (54–94) vs 9 (0–24) and 39% (17–64); P<0.05)), EOBI was most reliably detected by IL-8.
Conclusion:
LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI.
Keywords:
newborn, infection, lipopolysaccharide-binding protein, interleukin-8, C-reactive protein
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