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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Myelomeningocele in an Infant with Intrauterine Exposure to Efavirenz

Journal of Perinatology volume 25, pages 555–556 (2005)Cite this article

Abstract

We report a case of myelomeningocele in an infant whose mother was exposed to efavirenz during the first 16 weeks of pregnancy. Although the true risk for myelomeningocele with the use of efavirenz early in pregnancy is still unknown, the findings in humans are consistent with those observed in primates and suggest that efavirenz is a potent teratogen. Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available.

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Authors and Affiliations

  1. Division of Infectious Diseases (A.S., Department of Pediatrics, P.F., S.A.S.), University of California, San Diego, La Jolla, CA, USA

    Akihiko Saitoh MD, Patricia Franklin NP & Stephen A Spector MD

  2. Department of Reproductive Medicine (A.D.H.), University of California, San Diego, La Jolla, CA, USA

    Andrew D Hull MD

Authors
  1. Akihiko Saitoh MD
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  2. Andrew D Hull MD
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  3. Patricia Franklin NP
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  4. Stephen A Spector MD
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Saitoh, A., Hull, A., Franklin, P. et al. Myelomeningocele in an Infant with Intrauterine Exposure to Efavirenz. J Perinatol 25, 555–556 (2005). https://doi.org/10.1038/sj.jp.7211343

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