Original Article
Journal of Perinatology (2005) 25, 101–107. doi:10.1038/sj.jp.7211212 Published online 7 October 2004
Antenatal Risk Factors Associated with the Development of Lenticulostriate Vasculopathy (LSV) in Neonates
Robert Mittendorf MD, DrPH1, Karl Kuban MD, SM2, Peter G Pryde MD3, John G Gianopoulos MD1 and David Yousefzadeh MD4
- 1Department of Obstetrics and Gynecology (R.M., J.G.G.), Loyola University Medical Center, Maywood, IL
- 2Section of Pediatric Neurology (K.K.), Floating Hospital, Tufts University School of Medicine, Boston, MA
- 3University of Wisconsin Medical School (P.G.P.), Madison, WI
- 4Department of Radiology (D.Y.), Section of Pediatric Radiology, University of Chicago, Chicago, IL, USA
Correspondence: Robert Mittendorf, MD, DrPH, Department of Obstetrics and Gynecology, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
Abstract
OBJECTIVE:
To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).
STUDY DESIGN:
Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).
RESULTS:
Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 
50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).
CONCLUSION:
Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
NEWS AND VIEWS
Preterm birth, cerebral palsy and magnesium
Nature Medicine News and Views (01 Feb 1997)
RESEARCH
Journal of Perinatology Original Article
Identification of Isolated Lenticulostriate Vasculopathy in Preterm Infants
Journal of Perinatology Letter
Diffuse basal ganglia or thalamus hyperechogenicity in preterm infants
Journal of Perinatology Original Article
Journal of Perinatology Original Article
