Original Article
Journal of Perinatology (2005) 25, 86–89. doi:10.1038/sj.jp.7211208 Published online 14 October 2004
Follow-Up of Infants Exposed to Hydroxychloroquine Given to Mothers during Pregnancy and Lactation
Mario Motta MD1, Angela Tincani MD2, David Faden MD3, Enrica Zinzini MD4, Andrea Lojacono MD3, Alessandra Marchesi MD1, Micol Frassi MD2, Chiara Biasini MD2, Sonia Zatti MD3 and Gaetano Chirico MD1
- 1Division of Neonatology and NICU (M.M., A.M., G.C.), Spedali Civili - Brescia, Italy
- 2Division of Rheumatology and Clinical Immunology (A.T., M.F., C.B.), Spedali Civili - Brescia, Italy
- 3Division of Obstetrics and Gynecology (D.F., A.L., S.Z.), Spedali Civili - Brescia, Italy
- 4Division of Ophthalmology (E.Z.), Spedali Civili - Brescia, Italy
Correspondence: Mario Motta, MD, Division of Neonatology and Neonatal Intensive Care, Spedali Civili 25123 Brescia, Italy
Abstract
OBJECTIVE:
To determine the effect of hydroxychloroquine treatment during pregnancy and lactation on babies of mothers affected by rheumatic diseases.
STUDY DESIGN AND METHODS:
A total of 40 infants born from mothers affected by rheumatic diseases and treated with hydroxychloroquine during pregnancy were enrolled in a prospective observational study. Main outcome measures at birth were incidence of prematurity, congenital malformations and neonatal infections. Of these babies, including 13 who were breast-fed, 24 were followed up during early infancy for visual function and neurodevelopmental outcome.
RESULTS:
Preterm delivery was the main complication (20.5%). No significant congenital malformations or neonatal infections were detected. All infants, including those who were breast-fed, had normal visual function and neurodevelopmental outcome.
CONCLUSIONS:
Hydroxychloroquine treatment during gestation and lactation appeared to be safe. The relatively high incidence of preterm deliveries may reflect the maternal disease state.
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