Original Article

Journal of Perinatology (2005) 25, 33–35. doi:10.1038/sj.jp.7211199 Published online 2 September 2004

Can Oral Sucrose Reduce the Pain and Distress Associated with Screening for Retinopathy of Prematurity?

Joanna Grabska BS6, Peter Walden MD3, Trudy Lerer MS2, Christopher Kelly MD5, Naveed Hussain MBBS4, Terese Donovan MS4 and Victor Herson MD1

  1. 1Division of Neonatology (V.H.), Connecticut Children's Medical Center, Hartford, CT 06106, USA
  2. 2Division of Research (T.L.), Connecticut Children's Medical Center, Hartford, CT 06106, USA
  3. 3Division of Ophthalmology (P.W.), Connecticut Children's Medical Center, Hartford, CT 06106, USA
  4. 4Division of Neonatology (N.H., T.D.), University of Connecticut Health Center, Hartford, CT, USA
  5. 5Division of Ophthalmology (C.K.), University of Connecticut Health Center, Hartford, CT, USA
  6. 6Trinity Collge (J.G.), Hartford, CT, USA

Correspondence: Victor Herson, Division of Neonatology, Connecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA

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Abstract

OBJECTIVE:

 

Infants undergoing eye exams to screen for retinopathy of prematurity (ROP) demonstrate physiologic and behavioral manifestations of pain and distress. Oral sucrose has analgesic properties that might reduce these effects.

AIM:

 

To determine the efficacy of oral sucrose in reducing the pain/distress of eye exams for ROP.

METHODS:

 

A total of 32 infants about to undergo ROP screening exams received either oral sucrose [S] (N=16) or sterile water [C] (N=16) in a randomized, prospective and blinded fashion. Outcome measures included HR, RR, O2 saturation, BP, pain (premature infant pain profile) and percent of time spent crying during the eye exam.

RESULTS:

 

The groups were similar in GA (weeks) (28plusminus1.6), BW (kg) (1.04plusminus0.26), postnatal age (days) 50.8plusminus20.3, and study weight (kg) 1.88plusminus0.40). Both groups demonstrated significant increases in HR, BP, and pain score in response to the exam. Infants in both groups spent the majority of time actively crying during the exam ([S] 53plusminus35% vs [C] 63plusminus31%. Infants receiving [S] showed a small but significant drop in O2 saturation. No significant differences were seen between groups in physiologic or behavioral responses to the eye exam.

CONCLUSION:

 

Oral [S] was not effective in reducing pain/distress from the ROP screening exam. Alternative strategies should be considered to achieve adequate pain relief.

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