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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

High-frequency Partial Liquid Ventilation in Two Infants

Journal of Perinatology volume 24, pages 118–120 (2004)Cite this article

Abstract

Two infants on high-frequency oscillatory ventilation for chronic lung disease and severe respiratory failure, received a bolus of warmed and oxygenated perfluorodecalin up to residual functional capacity, followed by a continuous infusion of 6 ml/kg/hour. Our aim was to improve gas exchange without increasing ventilatory-induced lung injury. Heart rate, oxygen saturation, blood pressure, and TcPO2/TcPCO2 were continuously monitored during treatment. Arterial blood gas was evaluated every 3 hours. Both patients showed improvement of gas exchange with a 13.6 and 12.5% reduction of oxygenation index, respectively. High-frequency partial liquid ventilation is an experimental ventilation technique that could be considered as rescue treatment, to improve oxygenation in subjects with critical respiratory failure. This method could probably produce less damage, than other ventilation modes, to severely injured lungs.

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Authors and Affiliations

  1. Division of Neonatology and Neonatal Intensive care, Spedali Civili, Brescia, Italy

    Claudio Migliori MD, Roberto Bottino MD, Agnese Angeli MD, Donatella Cattarelli MD & Gaetano Chirico MD

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  1. Claudio Migliori MD
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  2. Roberto Bottino MD
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  3. Agnese Angeli MD
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  4. Donatella Cattarelli MD
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  5. Gaetano Chirico MD
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Migliori, C., Bottino, R., Angeli, A. et al. High-frequency Partial Liquid Ventilation in Two Infants. J Perinatol 24, 118–120 (2004). https://doi.org/10.1038/sj.jp.7211044

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