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Original Article |
The Effects of Exercise on Body Weight and Circulating Leptin in Premature Infants† |
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| Alon Eliakim MD1, Tzipora Dolfin MD2, Eli Weiss MSc3, Ruth Shainkin-Kestenbaum PhD4, Monica Lis MSc4 and Dan Nemet MD1,5 |
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1Department of Pediatrics, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
2Department of Neonatal Intensive Care Unit, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
3Endocrinology Laboratory, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
4Biochemical Laboratories, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
5Department of Pediatrics, Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, CA, USA
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Correspondence to: Dan Nemet, MD, General Clinical Research Center, UCI College of Medicine, 101 The City Drive, Building 25, 2nd Floor, Orange, CA 92868, USA |
†Biostatistics consult: MaryAnn Hill, PhD, Biostatistician, University of California, Irvine, CA 92868, USA.
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Abstract |
| OBJECTIVE: To assess the effect of daily movements on weight gain, serum leptin, and insulin-like growth factor I (IGF-I) in premature infants. STUDY DESIGN: Twenty very-low-birth-weight premature infants were matched and randomized to a daily movement (n=10) and control groups (n=10). Daily movement consisted of passive range of motion with gentle compression of both the upper and lower extremities 5 days per week for 4 weeks. RESULTS: Daily movements led to a significant increase in weight gain (784±51 vs 608±26 g in movements and controls, respectively, p<0.02), and to a significant increase in leptin (0.60±0.19 vs 0.13±0.06 ng/ml in movements and controls, respectively, p<0.05). Changes in body weight correlated with changes in serum leptin (r=0.48, p<0.03). IGF-I also increased following daily movements (18.8±4.1 vs 9.2±4.1 ng/ml in movements and controls, respectively); however, this increase was not statistically significant. CONCLUSION: A relatively brief range of motion daily movement intervention was associated with greater weight gain and increased leptin levels in very-low-birth-weight premature infants. This may suggest that at least part of the daily movements associated with increase in body weight resulted from an increase in adipose tissue. Journal of Perinatology (2002) 22, 550-554 doi:10.1038/sj.jp.7210788 |
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October/November 2002, Volume 22, Number 7, Pages 550-554 |
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