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  • Perinatal/Neonatal Casebook
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Perinatal/Neonatal Case Book

Efficacy of Phenytoin Against Hyponatremic Seizures Due to SIADH After Administration of Anticancer Drugs in a Neonate

Journal of Perinatology volume 22, pages 247–248 (2002)Cite this article

Abstract

A neonate with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) developed refractory hyponatremic seizures following administration of anticancer drugs. The seizures did not respond to diazepam, phenobarbital, or lidocaine, but resolved immediately with administration of phenytoin. The low water-excretion capacity in neonates should be taken into consideration when fluid loading is attempted, to avoid renal damage upon administration of drugs such as cisplatin that have a potential damaging effect on the kidney. Phenytoin could be the therapy of choice for SIADH and resulting seizures in the neonatal period.

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Authors and Affiliations

  1. Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan

    Miho Okamoto MD, Yasushi Nako MD, Atushi Tachibana MD, Thoru Fujiu MD, Yasushi Ohki MD, Takeshi Tomomasa MD & Akihiro Morikawa MD

Authors
  1. Miho Okamoto MD
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  2. Yasushi Nako MD
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  3. Atushi Tachibana MD
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  4. Thoru Fujiu MD
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  5. Yasushi Ohki MD
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  6. Takeshi Tomomasa MD
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  7. Akihiro Morikawa MD
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Okamoto, M., Nako, Y., Tachibana, A. et al. Efficacy of Phenytoin Against Hyponatremic Seizures Due to SIADH After Administration of Anticancer Drugs in a Neonate. J Perinatol 22, 247–248 (2002). https://doi.org/10.1038/sj.jp.7210657

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  • DOI: https://doi.org/10.1038/sj.jp.7210657

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