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  • Perinatal/Neonatal Casebook
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Perinatal/Neonatal Case Book

Inhaled Nitric Oxide for Oligohydramnios-Induced Pulmonary Hypoplasia: A Report of Two Cases and Review of the Literature

Journal of Perinatology volume 22, pages 82–85 (2002)Cite this article

Abstract

We describe the clinical courses of two premature infants, a male born at 294/7 weeks' gestational age after an 8-week period of rupture of membranes (ROM) and severe oligohydramnios, and a female infant born at 31 weeks' gestational age after an 18-week period of ROM and severe oligohydramnios. Within hours after birth, despite intubation and aggressive ventilation, both infants developed fulminant hypoxic respiratory failure. Their clinical courses were consistent with pulmonary hypertension and both infants were transferred for trials of inhaled nitric oxide (iNO). Both infants had dramatic responses to iNO, suggesting that the pulmonary disease seen after prolonged oligohydramnios may have a component of nitric oxide-sensitive pulmonary hypertension. The goals of this article are to (1) review oligohydramnios-induced pulmonary hypoplasia, (2) discuss patients at highest mortality risk, and (3) describe the effects of iNO on pulmonary hypertension in infants with hypoxemia following prolonged ROM and severe oligohydramnios.

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Authors and Affiliations

  1. Divisions of Neonatology and Pulmonary Biology, Children's Hospital Medical Center and Good Samaritan Hospital, Cincinnati, OH, USA

    Cara Geary MD, PhD & Jeffrey Whitsett MD

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  1. Cara Geary MD, PhD
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  2. Jeffrey Whitsett MD
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Geary, C., Whitsett, J. Inhaled Nitric Oxide for Oligohydramnios-Induced Pulmonary Hypoplasia: A Report of Two Cases and Review of the Literature. J Perinatol 22, 82–85 (2002). https://doi.org/10.1038/sj.jp.7210580

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