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December 2000, Volume 20, Number 8, Pages 555-557

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Clinical Perinatal/Neonatal Case Presentations

Successful Lysis of an Obstructive Aortic and Renal Artery Thrombus in a Neonate on Extracorporeal Membrane Oxygenation

Björn Gunnarsson1, Christopher MB Heard1,1,2, David J Martin1, Martin L Brecher1 and Robin H Steinhorn1

1Department of Pediatrics (B. G., C. M. B. H., M. L. B., R. H. S.), The Children's Hospital of Buffalo and State University of New York at Buffalo, Buffalo, NY

2Department of Anesthesiology (C. M. B. H.), The Children's Hospital of Buffalo and State University of New York at Buffalo, Buffalo, NY

Department of Radiology (D. J. M.), The Children's Hospital of Buffalo and State University of New York at Buffalo, Buffalo, NY

Correspondence to: Björn Gunnarsson MD , Division of Pediatric Critical Care, The Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222-2099.


Presented at the 15th Annual CNMC Symposium on ECMO and Advanced Respiratory Failure, Keystone, CO, USA.

Abstract

We describe a neonate on venoarterial extracorporeal membrane oxygenation (ECMO) with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis. Concurrent anticoagulation and continuous systemic thrombolytic therapy with tissue plasminogen activator (t-PA) resulted in complete thrombolysis as evaluated by Doppler flow. The relative risk and benefits of thrombolytic therapy in heparinized patients undergoing ECMO needs to be further studied. Journal of Perinatology (2000) 20: 555-557.

December 2000, Volume 20, Number 8, Pages 555-557

Table of contents    Previous  Abstract  Next   Article  PDF