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July-August 2000, Volume 20, Number 5, Pages 301-306 |
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Original Article |
Perinatal Factors Influencing Hepatic Glucose-6-Phosphatase Enzyme Activity† |
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| Robert Hume MBChB PhD, Anne McGeechan MBChB and Ann Burchell PhD |
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Departments of Obstetrics and Gynecology (R. H., A. B.) and Child Health (R. H., A. M.), Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee, Tayside, Scotland.
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Correspondence to: Robert Hume MBChB PhD, Department of Obstetrics and Gynecology, Tayside Instituteof Child Health, University of Dundee, Ninewells Hospital and MedicalSchool, Dundee, DD1 9SY Scotland. r.hume@dundee.ac.uk
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†The work carried out was supported by grants from the Scottish Home andHealth Department (to A. B. and R. H.), British DiabeticAssociation (to A. B.), Wellcome Trust (to R. H.), Tenovus(Scotland) (to R. H., A. B.), Research Trust for MetabolicDiseases in Children (to A. B.), Paediatric Metabolic ResearchTrust (to R. H.), and Northwood Charitable Trust (to A. B.).A. B. was a Lister Institute Research Fellow. Dr Simon Ogston,University of Dundee gave advice on statistical analysis.
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Abstract |
| BACKGROUND: At discharge from neonatal units, many preterm infants are vulnerable to preprandial hypoglycemia due to insufficient liver glucose production. In most preterm infants, hepatic glucose-6-phosphatase activity (the terminal step of liver glucose production) remains abnormally low postnatally. OBJECTIVE: To determine what perinatal factors are associated with changes in hepatic glucose-6-phosphatase enzyme activity. STUDY DESIGN: The maximum velocity (Vmax) of the hepatic microsomal glucose-6-phosphatase enzyme, as the dependant variable, was correlated by stepwise multiple regression analysis with clinical data from a consecutive series of 45 preterm infants from a level 3 neonatal unit. RESULTS: Significant factors (p £ 0.0005) were the presence of pathogenic bacteria isolated from maternal high vaginal swabs (p £ 0.0000), hyperkalemia regimen, duration of prenatal exposure to ritodrine, and delivery mode. Further analysis revealed that the highest correlation was with positive early postdelivery infant bacterial cultures. CONCLUSION: Perinatal events and clinical interventions modulate key enzyme systems necessary for human adaptation to extrauterine life. |
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July-August 2000, Volume 20, Number 5, Pages 301-306 |
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