TABLE 1
FROM:
Latest Insights into Skin Hyperpigmentation
Jean-Paul Ortonne and Donald L Bissett
BACK TO ARTICLETable 1. PIH on the forearm
| Test agent | Erythema grade (day 2) | PIH grade (day 11) |
|---|---|---|
| Vehicle | 2.09 | 0.93 |
| 5% phytosterol | 1.71* | 0.55* |
PIH, postinflammatory hyperpigmentation; SLS, sodium lauryl sulfate.
A 20% solution of SLS was applied to the forearm skin of Caucasian subjects (n=19) under occlusive patch (0.2 ml solution in a 19-mm-diameter chamber patch). The patch was removed after 1–4 h, depending on the individual subject responsiveness. After washing the site to remove surface SLS, the skin was treated topically twice daily for 5 days with test agent. The skin was graded (0–4 grading scales) daily for erythema and pigmentation (PIH) for 11 days (Unpublished work, D.L. Bissett).
*Statistically significantly different (P<0.05) versus vehicle.
