Original Article

Journal of Investigative Dermatology (1992) 98, 166–170; doi:10.1111/1523-1747.ep12555804

Common Pathogenetic Pathways in Allergic and Irritant Contact Dermatitis

Jochen Brasch, Jan Burgard and Wolfram Sterry

Department of Dermatology, University of Kiel, Kiel, FRG

Received 20 February 1991; Accepted 1 August 1991.

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Abstract

Despite their different pathogeneses, allergic and irritant contact dermatitis show a remarkable similarity with respect to clinical appearance, histology, and immunohistology. To further analyze this apparent contradiction, our study was designed to meticulously compare cellular infiltrates in irritant and allergic patch-test reactions by immunostaining with a broad panel of monoclonal antibodies. For this purpose, skin biopsies from allergic and irritant patch-test reactions of similar inflammatory degree were obtained from the same probands.

We found that after 72 h both types of reaction were characterized by an identical dermal infiltrate consisting mainly of memory T cells, many of which were activated, and macrophages. Dermal and epidermal Langerhans cell density and HLA–DR expression of keratinocytes were also virtually identical. Our results show that antigen recognition by specific memory T cells as well as irritants can finally induce the same pattern of inflammation, including activation of T cells obviously independent of exogenous antigen.

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