Original Article

Journal of Investigative Dermatology (1990) 94, 673–676; doi:10.1111/1523-1747.ep12876249

Genetic Control of Nickel Sulfate Delayed-Type Hypersensitivity

Norihisa Ishii1, Harumi Ishii1, Hideki Ono1, Yoshihito Horiuchi1, Hiroshi Nakajima1 and Ichiro Aoki2

  1. 1Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
  2. 2Department of Pathology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan

Received 31 May 1989; Accepted 9 October 1989.

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Abstract

Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfate DTH may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+ Lyt-2- T cells.

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References

  1. Krco, CJ, David, CS: Genetics of immune response: A survey. CRC Crit Rev Immunol 1981 8: 211–257,
  2. Bösze, Z, Fachet, J: Genetic control of the proliferative response to oxazolone in H-2 congenic and recombinant strains of mice. Immunology 1979 38: 749–755,
  3. Okuda, K, Ishii, N, Ikezawa, Z, Tani, K, Ishigatsubo, Y: Genetic control of contact hypersensitivity. I. I-A subregion as well as non-H-2 loci codes for the gene of 2,4-dinitro-1-fluorobenzene antigen. Eur J Immunol 1980 10: 969–971,
  4. Menné, T, Holm, NV: Hand eczema in nickel-sensitive female twins. Genetic predisposition and environmental factors. Contact Dermatitis 1983 9: 289–296,
  5. Olerup, O, Emtestam, L: Allergic contact dermatitis to nickel is associated with a Taq I HLA-DQA allelic restriction fragment. Immunogenetics 1988 28: 310–313,
  6. Emtestam, L, Marcusson, JA, Möller, E: HLA class II restriction specificity for nickel-reactive T lymphocytes. Acta Derm Venereol (Stockh) 1988 68: 395–401,
  7. Kieffer, M: Nickel sensitivity: Relationship between history and patch test reaction. Contact Dermatitis 1979 5: 398–401,
  8. Peltonen, L: Nickel sensitivity in the general population. Contact Dermatitis 1979 5: 27–32,  | PubMed | ISI | ChemPort |
  9. Geczy, AF, Weck, AL DE: Genetic control of sensitization to structurally unrelated antigens and its relationship to histocompatibility antigens in guinea-pigs. Immunology 1975 28: 331–342,  | PubMed |
  10. Möller, H: Attempts to induce contact allergy to nickel in the mouse. Contact Dermatitis 1984 10: 65–68,  | Article | PubMed | ChemPort |
  11. Mikac-Devic acute, D, Sunderman, FW Jr, Nomoto, S: Furildioxime method for nickel analysis in serum and urine by electrothermal atomic absorption spectrometry. Clin Chem 1977 23: 948–956,
  12. Ishii, N, Nakajima, H, Aoki, I, Ishii, T, Takahashi, T, Okuda, K: Delayed type hypersensitivity to allogeneic mouse epidermal cell antigens. I. Lyt-1+2-T cells are important for DTH. Immunogenetics 1986 23: 351–356,  | Article | PubMed | ChemPort |
  13. Ishii, N, Ichiyama, S, Ishii, T, Aoki, I, Okuda, K, Nakajima, H: Genetic control of delayed-type hypersensitivity to D-penicillamine antigen. Int Arch Allergy Appl Immun 1988 85: 150–153,
  14. Ishii, N, Aoki, I, Aihara, Y, Hikawa, N, Takahashi, T, Okuda, K: Analysis of hen egg white lysozyme (HEL)-specific delayed type hypersensitivity hybridomas. Hybridoma 1985 4: 311–318,
  15. Sinigaglia, F, Scheidegger, D, Garotta, G, Scheper, R, Pletscher, M, Lanzavecchia, A: Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immunol 1985 135: 3929–3932,  | PubMed | ISI | ChemPort |
  16. Kapsenberg, ML, Res, P, Bos, JD, Schootemijer, A, Teunissen, MBM, Schooten, WV: Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen-presenting cell subsets. Eur J Immunol 1987 17: 861–865,  | PubMed | ISI | ChemPort |
  17. Nagy, ZA, Baxevanis, CN, Ishii, N, Klein, J: Ia antigens as restriction molecules in Ir-gene controlled T-cell proliferation. Immunol Rev 1981 60: 59–83,
  18. Res, P, Kapsenberg, ML, Bos, JD, Stiekema, F: The crucial role of human dendritic antigen-presenting cell subsets in nickel-specific T-cell proliferation. J Invest Dermatol 1987 88: 550–554,  | Article | PubMed | ChemPort |

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