Original Article

Journal of Investigative Dermatology (1988) 91, 532–535; doi:10.1111/1523-1747.ep12476881

193 nm Excimer Laser Selective Ablation of In Vivo Guinea Pig Epidermis

Joseph G Morelli1, Abdul-Ghani Kibbi2, James Boll3 and Oon Tian Tan4

  1. 1Department of Dermatology, University of Colorado Medical Center, Denver, Colorado
  2. 2Department of Dermatology, American Hospital, Beirut, Lebanon
  3. 3Candela Laser Corporation, Wayland, Massachusetts
  4. 4Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts

Received 29 December 1987; Accepted 29 June 1988.

Top

Abstract

We have previously shown that 193 nm excimer laser irradiation cleanly and effectively ablates avascular tissue with minimal thermal damage to surrounding adjacent structures. In this study, the 193 nm excimer laser is used to remove guinea pig epidermis in vivo. The epidermis can be totally ablated with thermal damage extending only superficially into the dermis. Reepitheliazation of the ablated area takes place in 1 week or less. This technique may be applicable to the removal of benign epidermal lesions.

Top

References

  1. Nakagawa, H, Tan, OT, Parrish, JA: Ultrastructural changes in human skin after exposure to a pulsed laser. J Invest Dermatol 1985 84: 396–400,  | Article | PubMed | ChemPort |
  2. Morelli, J, Tan, OT, Garden, J, Margolis, R, Seki, Y, Boll, J, Carney, M, Anderson, RR, Furumoto, H, Parrish, JA: Tunable dye laser (577 nm) treatment of portwine stains. Lasers Surg Med 1986 6: 94–99,  | PubMed | ChemPort |
  3. Tan, OT, Carney, M, Margolis, R, Seki, Y, Boll, J, Anderson, RR, Parrish, JA: Histologic responses of portwine stains treated by argon, carbon dioxide, and tunable dye lasers: a preliminary report. Arch Dermatol 1986 122: 1016–1022,  | Article | PubMed | ISI | ChemPort |
  4. Garden, J, Tan, OT, Parrish, JA: The pulsed dye laser: its use at 577 nm wavelength. J Dermatol Surg Oncol 1987 13: 134–138,  | PubMed | ChemPort |
  5. Tan, OT, Stafford, TJ: Treatment of portwine stain at 577 nm: Clinical results. Medical Instrumentation 1987 21: 218–221,  | PubMed | ChemPort |
  6. Tan, OT, Whitaker, D, Garden, J, Murphy, G: Pulsed dye laser (577 nm) treatment of portwine stains: Ultrastructural evidence of neovascularization and mast cell degranulation in healed lesions. J Invest Dermatol 1988 90: 395–398,  | Article | PubMed | ChemPort |
  7. Garden, J, Tan, OT, Kerschmann, R, Boll, J, Parrish, JA: Effect of pulse-width on vessel specific changes induced by a pulsed laser radiation. J Invest Dermatol 1986 87: 653–657,  | Article | PubMed | ISI | ChemPort |
  8. Anderson, RR, Parrish, JA: Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 1983 220: 524–527,  | PubMed | ISI | ChemPort |
  9. Polla, LL, Margolis, RJ, Dover, JS, Whitaker, D, Murphy, GF, Jacques, SL, Anderson, RR: Melanosomes are a primary target of Q switched ruby laser irradiation in guinea pig skin. J Invest Dermatol 1987 89: 281–286,  | Article | PubMed | ISI | ChemPort |
  10. Dougherty, TJ, Weishaup, KR, Boyl, DB: Photosensitizers. In: Devita VT Jr., Hellman S, Rosenberg SA (eds.). Cancer: Principles and Practice of Oncology 1982 JB Lippincott, Philadelphia, pp 1836–1844,
  11. Hayashhi, K, deLaey, JJ: Indocyanine green angiography of choroidal neovascular membranes. Ophthalmologica 1985 190: 30–39,  | PubMed |
  12. Morelli, J, Tan, OT, Kibbi, A, Farinelli, W, Parrish, JA: Ultraviolet excimer laser ablation: Effects of wavelength and repetition rate on the in vivo guinea pig skin. J Invest Dermatol 1987 88: 769–773,  | Article | PubMed | ChemPort |
  13. Carney, J, Olbricht, S, Stern, R, Arndt, K: CO2 laser vs. electrosurgery in the treatment of warts. Lasers Surg Med 1986 6: 186,
  14. Bailin, PL: Use of the CO2 laser for non-PWS Cutaneous Lesions. In: Arndt KA, Noe JM, Rosen S (eds.). Cutaneous Laser Therapy: Principles and Methods 1983 John Wiley and Sons, pp 187–200,
  15. McBurney, E, Rosen, D: Carbon dioxide laser treatment of verrucae vulgaris. J Dermatol Surg Oncol 1984 10: 45–48,  | PubMed | ChemPort |
  16. Green, HA, Margolis, M, Boll, J, Kochevar, IE, Parrish, JA, Oseroff, AR: Unscheduled DNA synthesis in human skin after in vitro ultraviolet excimer laser ablation. J Invest Dermatol 1987 89: 201–204,  | Article | PubMed | ChemPort |

Extra navigation

.
ADVERTISEMENT