Original Article

Journal of Investigative Dermatology (1985) 84, 187–190; doi:10.1111/1523-1747.ep12264802

Subcutaneous Blood Flow in Psoriasis

Per Klemp

Departments of Dermatology and Clinical Physiology, The Finsen Institute, Copenhagen, Denmark

Received 16 May 1984; Accepted 14 September 1984.

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Abstract

The simultaneously recorded disappearance rates of 133Xe from subcutaneous adipose tissue in the crus were studied in 10 patients with psoriasis vulgaris using atraumatic labeling of the tissue in lesional skin (LS) areas and symmetrical, nonlesional skin (NLS) areas. Control experiments were performed bilaterally in 10 younger, healthy subjects. The subcutaneous washout rate constant was significantly higher in LS, 0.79 plusminus 0.05 min-1. 102 compared to the washout rate constant of NLS, 0.56 plusminus 0.07 min-1. 102 (p < 0.05), or the washout rate constant in the normal subjects, 0.46 plusminus 0.17 min-1. 102 (p <0.01). The mean washout rate constant in NLS was 25% higher than the mean washout rate constant in the normal subjects. The difference was, however, not statistically significant. Differences in the washout rate constants might be due to abnormal subcutaneous tissue-to-blood partition (lambda) in the LS—and therefore not reflecting the real differences in the subcutaneous blood flow (SBF). The lambda for133Xe was therefore measured—using a double isotope washout method (133Xe and [133I]antipyrine)—in symmetrical sites of the lateral crus in LS and NLS of 10 patients with psoriasis vulgaris and in 10 legs of normal subjects. In LS the lambda was 4.52 plusminus 1.67 ml/g, which was not statistically different from that of NLS, 5.25 plusminus 2.19 ml/g (p < 0.05), nor from that of normal subcutaneous tissue, 4.98 plusminus 1.04 ml/g (p < 0.05). Calculations of the SBF using the obtained lambda values gave a significantly higher SBF in LS, 3.57 plusminus 0.23 ml/100 g/min, compared to SBF in the NLS, 2.94 plusminus 0.37 ml/100 g/min (p < 0.05). There was no statistically significant difference between SBF in NLS and SBF in the normal subjects. The increased SBF in LS of psoriatics might be a secondary phenomenon to an increased heat loss in the lesional skin.

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