Original Article

Journal of Investigative Dermatology (1982) 79, 368–373; doi:10.1111/1523-1747.ep12529734

Itch Evoked by Electrical Stimulation of the Skin

Robert P Tuckett

Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A.

Received 16 October 1981; Accepted 6 April 1982.

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Abstract

Psychophysical experiments were done to test the possibility that a single receptor population signals both itch and pain by generating different patterns of activity for each type of stimulus. Electrical stimulation of hairy skin evoked pruritus in 92% of the subjects tested, and for the majority the pruritus elicited by electrical stimulation felt the same as that provoked by cowhage. The intensity of pruritus increased with the frequency of stimulation with no change in the quality of the sensation from itch to pain. Electrical stimulation of human skin with response patterns obtained from individual cat polymodal nociceptive neurons to pain- and itch-producing stimuli caused no differences in the quality of the evoked pruritic sensations. These results do not support the idea that the same population of primary sensory neurons can produce both itch and pain by changing their pattern of discharge.

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References

  1. Boring, EG: Sensation and Perception in the History of Experimental Psychology 1942 New York, Appleton-Century-Crofts, Inc,
  2. Noordenbos, W: Pain 1959 New York, Elsevier,
  3. Quilliam, TA: Cutaneous sensation reconsidered. Med Biol Illus 1971 21: 183–187,  | PubMed |
  4. Nafe, JP: A quantitative theory of feeling. J Gen Psychol 1929 2: 199–210,
  5. Sinclair, DC: Cutaneous sensation and the doctrine of specific energy. Brain 1955 78: 584–614,  | PubMed |
  6. Weddell, G, Miller, S: Cutaneous sensibility. Ann Rev Physiol 1962 24: 199–222,
  7. Melzack, R, Wall, PD: On the nature of cutaneous sensory mechanisms. Brain 1962 85: 331–356,  | PubMed |
  8. Heinbecker, P, Bishop, GH, O'Leary, J: Pain and touch fibers in peripheral nerves. Arch Neurol Psychiat 1933 29: 771–789,
  9. Collins, WF, Nulsen, FE, Randt, CT: Relation of peripheral nerve fiber size and sensation in man. Arch Neurol 1970 3: 381–385,
  10. Muller, J: Elements of Physiology 1838 1: Translated by W Baly. London, Taylor & Walton,
  11. Sherrington, CS: The Integrative Action of the Nervous System 1906 New Haven, Yale University Press,
  12. Adrian, ED: The messages in sensory nerve fibres and their interpretation. Proc R Soc Lond [Biol] 1931 109: 1–18,
  13. Hensel, H: Cutaneous thermoreceptors, Handbook of Sensory Physiology, Somatosensory System 1973 2: Edited by A Iggo. New York, Springer-Verlag, pp 79–110,
  14. Burgess, PR, Perl, ER: Cutaneous mechanoreceptors and nociceptors, Handbook of Sensory Physiology, Somatosensory System 1973 2: Edited by A Iggo. New York, Springer-Verlag, pp 29–78,
  15. Iggo, A: Cutaneous receptors, The Peripheral Nervous System 1974 Edited by JI Hubbard. New York, Plenum, pp 347–404,
  16. Iggo, A: A single unit analysis of cutaneous receptors with C afferent fibres 1959 CIBA Study Group #1, Pain and Itch. Boston, Little, Brown, pp 41–56,
  17. Bessou, P, Perl, ER: Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 1969 32: 1025–1043,  | PubMed | ISI | ChemPort |
  18. Burgess, PR, Perl, ER: Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J Physiol (Lond) 1967 190: 541–562,  | PubMed |
  19. Fitzgerald, M, Lynn, B: The sensitization of high threshol mechanoreceptors with myelinated axons by repeated heating. J Physiol (Lond) 1977 265: 549–563,  | PubMed |
  20. Torebjork, HE, Hallin, RG: Skin receptors supplied by unmyelinated (C) fibres in man, Sensory Functions of the Skin in Primates 1976 Edited by Y Zotterman. New York, Pergamon, pp 475–485,
  21. Torebjork, HE, Ochoa, JL: Specific sensations evoked by activity in single identified sensory units in man. Acta Physiol Scand 1980 110: 445–447,  | PubMed |
  22. Tuckett, RP: Response of cutaneous receptors to a pruritic stimulus. Neurosci Abstr 1980 6: 428,
  23. Perl, ER: Sensitization of nociceptors and its relation to sensation, Advances in Pain Research and Therapy 1976 1: Edited by JJ Bonica, D Albe-Fessard. New York, Raven, pp 17–28,
  24. Keele, CA, Armstrong, D: Substances Producing Pain and Itch 1964 Baltimore, Williams & Wilkins,
  25. Sinclair, D: Cutaneous Sensation 1967 New York, Oxford Univ Press,
  26. Rothman, S: Physiology of itching. Physiol Rev 1941 21: 357–381,
  27. Bishop, GH: The skin as an organ of senses with special reference to the itching sensation. J Invest Dermatol 1948 11: 143–154,
  28. Wall, PD, Cronly-Dillon, JR: Pain, itch, and vibration. Arch Neurol 1960 2: 365–375,  | PubMed |
  29. Hagermark, O, Hokfelt, T, Pernow, B: Flare and itch induced by substance P in human skin. J Invest Dermatol 1978 71: 233–235,  | Article | PubMed | ChemPort |
  30. Price, DD, Dubner, R: Neurons that subserve the sensory-discriminative aspects of pain. Pain 1977 3: 307–338,  | Article | PubMed | ISI | ChemPort |
  31. Bishop, GH: Responses to electrical stimulation of single sensory units of skin. J Neurophysiol 1943 6: 361–382,
  32. Sigel, H: Prick threshold stimulation with square-wave current: a new measure of skin sensibility. Yale J Biol Med 1953 26: 145–154,  | PubMed |
  33. Shelley, WB, Arthur, RP: The neurohistology and neurophysiology of the itch sensation in man. Arch Dermatol 1957 76: 296–323,  | ISI | ChemPort |
  34. Edwards, AE, Shellow, WVR, Wright, ET, Dignam, TF: Pruritic skin disease, psychological stress, and the itch sensation. A reliable method for the induction of experimental pruritus. Arch Dermatol 1976 112: 339–343,  | Article | PubMed |
  35. Tuckett, RP: Pruritus evoked by electrical, cutaneous stimulation. Neurosci Abtr 1981 7: 531,
  36. Tuckett, RP, Horch, KW, Burgess, PR: Response of cutaneous hair and field mechanoreceptors in cat to threshold stimuli. J Neurophysiol 1978 41: 138–149,  | PubMed |
  37. LaMotte, RH, Campbell, JN: Comparison of responses of warm and nociceptive C-fiber afferents monkey with human judgments of thermal pain. J Neurophysiol 1978 41: 509–528,  | PubMed | ISI | ChemPort |
  38. Shelley, WB, Arthur, RP: Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain. Arch Dermatol 1955 72: 399–406,
  39. Marks, LE: Sensory Processes. The New Psychophysics 1974 New York, Academic,
  40. Broadbent, JL: Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation. Br J Pharmacol 1953 8: 263–270,  | ChemPort |
  41. Graham, DT, Goodell, H, Wolff, HG: Neural mechanisms involved in itch, "itchy skin," and tickle sensations. J Clin Invest 1951 30: 37–49,  | PubMed | ISI | ChemPort |
  42. Bickford, RG: Experiments relating to the itch sensation, its peripheral mechanism, and central pathways. Clin Sci 1938 3: 377–386,
  43. Hagermark, O: Studies on experimental itch induced by kallikrein and bradykinin. Acta Derm Venereol (Stockh) 1974 54: 397–400,
  44. Torebjork, HE, Ochoa, JL: Pain and itch from C fiber stimulation. Neurosci Abstr 1981 7: 228,
  45. Campbell, JN, Meyer, RA, Jaffe, SR: Evidence for two distinct classes of unmyelinated nociceptive afferents responsive to mechanical and thermal stimuli in the monkey. Neurosci Abstr 1981 7: 228,
  46. Anderson, AB, Munson, WA: Electrical excitation of nerves in the skin at audiofrequencies. J Acoust Soc Am 1951 23: 155–159,  | Article |
  47. Gilmer, BVH: Toward cutaneous electropulse communication. J Psychol 1961 52: 211–222,
  48. Gibson, RH: Electrical stimulation of pain and touch, The Skin Senses 1968 Edited by DR Kenshalo. Springfield, Illinois, Charles C Thomas, pp 223–261,
  49. Suunders, FA: Recommended procedures for electrocutaneous displays, Functional Electrical Stimulation 1977 Edited by FT Hambrecht, JB Reswick. New York, Dekker, pp 303–309,
  50. Sachs, RM, Miller, JD, Grant, KW: Perceived magnitude of multiple electrocutaneous pulses. Percept Psychophys 1980 28: 255–262,  | PubMed |
  51. Li, CL, Bak, A: Excitability characteristics of the A- and C-fibers in a peripheral nerve. Exp Neurol 1976 50: 67–79,  | Article | PubMed | ChemPort |
  52. Pfeiffer, EA: Electrical stimulation of sensory nerves with skin electrodes for research, diagnosis, communication and behavioral conditioning: a survey. Med Biol Eng 1968 6: 637–651,  | PubMed |
  53. Mason, JL, Mackay, NAM: Pain sensations associated with electrocutaneous stimulation. IEEE Trans Biomed Eng 1976 23: 405–409,  | PubMed |
  54. Hahn, JF: Cutaneous vibratory thresholds for square-wave electrical pulses. Science 1958 127: 879–880,  | PubMed |
  55. Hawkes, GR: Cutaneous communication: absolute identification of electrical intensity level. J Psychol 1960 49: 203–212,
  56. Ekman, G, Frankenhaeuser, M, Levander, S, Mellis, I: Scales of unpleasantness of electrical stimulation. Scand J Psychol 1964 5: 257–261,
  57. Plutchik, R, Bender, H: Electrocutaneous pain thresholds in humans to low frequency square-wave pulses. J Psychol 1966 62: 151–154,  | PubMed |
  58. Adrian, ED: The response of human sensory nerves to currents of short duration. J Physiol (Lond) 1919 53: 70–85,
  59. Lewis, T: Experiments relating to cutaneous hyperalgesia and its spread through somatic nerves. Clin Sci 1935 2: 373–423,
  60. Notermans, SLH: Measurement of the pain threshold determined by electrical stimulation and its clinical application. I. Method and factors possibly influencing the pain threshold. Neurology 1966 16: 1071–1086,  | PubMed |
  61. Sternbach, RA, Tursky, B: Ethnic differences among housewives in psychophysical and skin potential responses to electric shock. Psychophysiology 1965 1: 241–246,
  62. Vierck, CJ Jr, Luck, MM: Loss and recovery of reactivity to noxious stimuli in monkeys with primary spinothalamic cordotomies, followed by secondary and tertiary lesions of other cord sectors. Brain 1979 102: 233–248,  | PubMed |
  63. Lewis, T, Grant, RT, Marvin, HM: Vascular reactions of the skin to injury. X. The intervention of a chemical stimulus illustrated especially by the flare. The response to faradism. Heart 1927 14: 139–160,
  64. Tursky, B, O'Connell, D: Reliability and interjudgment predictability of subjective judgments of electrocutaneous stimulation. Psychophysiology 1972 9: 290–295,  | PubMed |
  65. Chen-yu, C, Ching-tsai, C, Hsiu-ling, C, Lian-fang, Y: Peripheral afferent pathway for acupuncture analgesia. Sci Sin 1973 16: 210–217,
  66. Tursky, B, Watson, PD: Controlled physical and subjective intensities of electric shock. Psychophysiology 1964 1: 151–162,

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