Original Article

Journal of Investigative Dermatology (1982) 78, 253–255; doi:10.1111/1523-1747.ep12506612

Inhibition of Sebaceous Gland Activity by Spironolactone in Syrian Hamster

Christoph Luderschmidt1, Frank Bidlingmaier2 and Gerd Plewig1

  1. 1Department of Dermatology, University of Munich, Munich, Federal Republic of Germany
  2. 2Department of Pediatrics, University of Munich, Munich, Federal Republic of Germany

Received 18 February 1981; Accepted 1 September 1981.

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Abstract

In the animal model of the Syrian hamster the antiandrogenic action of spironolactone on the sebaceous glands of the ventral side of the pinna was examined. Spironolactone reduces both labeling index and cross-sectional surface area of sebaceous glands significantly in a dose-dependent manner. Equally there was a significant decrease in serum testosterone levels in spironolactone treated animals. Our results seem to justify clinical studies with spironolactone in patients with hirsutism, serborrhea, and possibly acne vulgaris.

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