Journal of Investigative Dermatology (1977) 68, 328–335; doi:10.1111/1523-1747.ep12496022
ORAL METHOXSALEN PHOTOCHEMOTHERAPY FOR THE TREATMENT OF PSORIASIS: A COOPERATIVE CLINICAL TRIAL
John W Melski1,2, Lewis Tanenbaum1,2, John A Parrish1,2, Thomas B Fitzpatrick1,2 and Howard L Bleich1,2
- 1Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, U.S.A.
- 2Thorndike Laboratory and Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts, U.S.A.
Top of pageAbstract
Extensive psoriasis in 1,308 patients has been treated two or three times a week with oral 8-methoxypsoralen followed by high intensity, long-wave ultraviolet light (PUVA). Excluding 169 patients still under early treatment, psoriasis cleared in 88% and failed to clear in 3%. One percent dropped out due to complications of treatment, and 8% for other reasons. The twice-a-week schedule was superior for patients with lighter skin types. Once a remission was induced, there was no difference in its maintenance when patients were treated once a week, once every other week, or once every third week. Each of these schedules was superior to no maintenance treatment, immediate side effects of the 45,000 treatments administered in the first 18 months of this study were uncommon, temporary, and generally mild. No clinically significant changes in laboratory screening or eye examinations attributable to PUVA have been uncovered.
Top of pageReferences
- Parrish, JA, Fitzpatrick, TB, Tanenbaum, L, Pathak, MA: Photochemotherapy of psoriasis with oral methoxsalen and long wave ultraviolet light. N Engl J Med 1974 291: 1207–1212, | PubMed | ISI | ChemPort |
- Levin, RE, Parrish, JA: Phototherapy of vitiligo. Lighting Design and Application 1974 4: 38,
- Karpinski, HS, Bleich, HL: MISAR: A miniature information storage and retrieval system. Comput Biomed Res 1971 4: 655–660, | Article | PubMed | ChemPort |
- McGee, VE: Principals of Statistics: Traditional and Bayesian 1971 New York, Appleton-Century-Crofts,
- Merrell, M, Shulman, L: Determination of prognosis in chronic diseases. J Chron Dis 1955 1: 12–32, | Article | PubMed | ChemPort |
- Cutler, S, Ederer, F: Maximum utilization of the life table method in analyzing survival. J Chron Dis 1958 8: 699–712, | Article | PubMed | ChemPort |
