Original Article

Journal of Investigative Dermatology (1975) 65, 532–536; doi:10.1111/1523-1747.ep12610281

ANTI-INFLAMMATORY EFFECTS OF ANTIMICROBIAL AGENTS: AN IN VIVO STUDY

Gerd Plewig1 and Erwin Schöpf2

  1. 1Department of Dermatology, University of Munich, Munich, West Germany
  2. 2Department of Dermatology, University of Heidelberg, Heidelberg, West Germany

Received 13 May 1975; Revised 23 July 1975; Accepted 29 July 1975.

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Abstract

Antimicrobials are used emperically in a variety of inflammatory dermatoses such as rosacea and dermatitis herpetiformis, although these diseases are not believed to be of bacterial etiology. We have used potassium iodide ointment to induce follicular pustules and have found in this in vivo model properties of antimicrobials not related to their antibacterial actions. Topical demethylchlortetracycline and erythromycin (5%) lead to suppression of KI-induced inflammation (erythema, pustules) and systemic use of these drugs as well as diaminodiphenylsulfone produces the same effect.

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References

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