Original Article

Journal of Investigative Dermatology (1974) 62, 463–466; doi:10.1111/1523-1747.ep12701707

THE EFFECTS OF INTRADERMAL STEROIDS ON THE PITUITARY-ADRENAL AXIS AND THE SKIN

Michael T Jarratt, Richard F Spark and Kenneth A Arndt

Departments of Dermatology and Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts

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Abstract

The effects of three commonly used corticosteroid preparations on the pituitary-adrenal axis and the skin were studied following graded intradermal injections. Betamethasone acetate-phosphate suspension was more suppressive to the pituitary-adrenal axis than equivalent doses of either triamcinolone acetonide or triamcinolone diacetate. However, the long-term local effects of intradermal corticosteroids (hypopigementation, atrophy, telangiectasia) were more marked following the use of the triamcinolone formulations.

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