Original Article

Journal of Investigative Dermatology (1974) 62, 217–223; doi:10.1111/1523-1747.ep12676787

RECEPTOR PROTEINS FOR ANDROGEN IN HAMSTER SEBACEOUS GLANDS

Kenji Adachi1,2

  1. 1Dermotology Service, Veterans Administration Hospital, Miami, Florida
  2. 2University of Miami, Miami, Florida
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Abstract

Chromatographic and ultracentrifugal techniques demonstrate that receptor proteins in hamster sebaceous glands play important biologic roles such as recognition, transfer, retention, and protection of the tissue-active androgen dihydrotestosterone. Since this is the first step of androgen action, any interference of the binding causes a loss of subsequent biologic sequellae, such as the stimulation of energy metabolism. Both the synthesis and degradation of the receptor proteins are highly dependent on dihydrotestosterone levels. The short half lives of the receptor proteins and of the messenger RNA for the receptors further contribute to the essential role of androgen receptors in controlling the dynamic actions of androgen in hamster sebaceous glands.

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References

  1. Adachi, K, Kano, M: The role of receptor proteins in controlling androgen action in the sebaceous glands of hamsters. Steroids 1972 19: 567–574,  | PubMed | ChemPort |
  2. Adachi, K, Takayasu, S: The mechanisms of testosterone action on the sebaceous glands of the Syrian hamster. In: Pharmacology and the Skin 1972 (ed. by Montagna, W., Stoughton, R. B., and Van Scott, E. J.). Appleton-Century-Crofts, New York, pp 381–401,
  3. Adachi, K, Uno, H: Glucose metabolism of growing and resting human hair follicles. Am. J. Physiol 1908 215: 1234–1239,
  4. Anderson, KM, Liao, S: Selective retention of dihydrotestosterone by prostatic nuclei. Nature (Lond.) 1968 219: 277–279,  | ChemPort |
  5. Baulieu, EE, Jung, I: A prostatic cytosol receptor. Biochem. Biophys. Res. Commun 1970 38: 599–606,  | Article | PubMed | ChemPort |
  6. Bruchovsky, N, Wilson, JD: Evidence that dihydrotestosterone is the active form of testosterone. Clin. Res 1968 14: 74,
  7. Bruchovsky, N, Wilson, JD: The conversion of testosterone to 5alpha-androstan-17beta-ol-3-one by rat prostate in vivo and in vitro. J. Biol. Chem 1968 243: 2012–2021,  | PubMed | ISI | ChemPort |
  8. Bruchovsky, N, Wilson, JD: The intranuclear binding of testosterone and 5alpha-androstan17beta-ol-3-one by rat prostate. J. Biol. Chem 1968 243: 5943–5960,
  9. DeAngelo, AB, Gorski, J: Role of RNA synthesis in the estrogen induction of a specific uterine protein. Proc. Natl. Acad. Sci. U.S.A 1970 66: 693–700,  | Article | PubMed | ChemPort |
  10. Fang, S, Anderson, KM, Liao, S: Receptor proteins for androgens. On the role of specific proteins in selective retention of 17beta-hydroxy-5alpha-androstan-3-one by rat ventral prostate in vivo and in vitro. J. Biol. Chem 1969 244: 6584–6595,  | PubMed | ChemPort |
  11. Fang, S, Liao, S: Androgen receptors. J. Biol. Chem 1971 246: 16–24,  | PubMed | ChemPort |
  12. Hamilton, JB, Montagna, W: The sebaceous glands of the hamsters. I. Morphological effects of androgens on integumentary sturctures. Am. J. Anat 1950 86: 191–234,  | Article | PubMed | ChemPort |
  13. Jensen, EV, Suzuki, T, Kawashima, T, Stumpf, WE, Jungblut, PW, DeSombre, ER: A two-step mechanism for the interaction of estradiol with rat uterus. Proc. Natl. Acad. Sci. U.S.A 1968 59: 632–638,  | Article | PubMed | ChemPort |
  14. Strauss, JS, Pochi, PE: Recent advances in androgen metabolism and their relation to the skin. Arch. Dermatol 1969 100: 621–636,  | Article | PubMed | ChemPort |
  15. Takayasu, S, Adachi, K: Hormonal control of metabolism in hamster costovertebral glands. J. Inves. Dermatol 1970 55: 13–19,  | ChemPort |
  16. Takayasu, S, Adachi, K: The in vivo and in vitro conversion of testosterone to 17beta-hydroxy-5alpha-androstan-3-one (dihydrotestosterone) by the sebaceous gland of hamsters. Endocrinology 1972 90: 73–80,  | PubMed | ChemPort |
  17. Tymoczko, JL, Liao, S: Retention of an androgen-protein complex by nuclear chromatin aggregates: Heat-labile factors. Biochim. Biophys. Acta 1971 252: 607–611,  | PubMed | ChemPort |

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