Original Article

Journal of Investigative Dermatology (1972) 59, 416–420; doi:10.1111/1523-1747.ep12627594

EFFECTS OF LONG ULTRAVIOLET RAYS ON HUMAN SKIN: PHOTOPROTECTIVE OR PHOTOAUGMENTATIVE?

Isaac Willis1, Albert Kligman2 and John Epstein3

  1. 1Sub-Department of Dermatology, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, 21205
  2. 2Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19140
  3. 3Division of Dermatology, University of California Medical Center, San Francisco, California, 94122

Received 12 April 1972; Accepted 20 June 1972.

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Abstract

The effects of long ultraviolet (LUV) rays on human skin are generally believed to be either harmless or protective against sunburn damage. Responses to LUV alone, LUV plus sunburn radiation, and sunburn radiation alone were evaluated both clinically and microscopically by routine histologic and autoradiographic techniques. Observations revealed that contrary to previous accepted hypotheses, LUV rays have a striking augmentative effect on sunburn damage. In addition, although LUV radiation alone causes no discernable adverse clinical or histologic changes in skin, an effect on DNA metabolism does occur.

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References

  1. Bachem, A: Time factors of erythema and pigmentation produced by ultraviolet rays of different wavelengths. J Invest Dermatol 1955 25: 215,  | PubMed | ChemPort |
  2. Briet, R, Kligman, AM: Measurement of erythemal and pigmentary responses to ultraviolet radiation of different spectral qualities. The Biologic Effects of Ultraviolet Radiation Edited by F Urbach. Oxford, Pergamon Press, pp 267–275,
  3. Pathak, MA, Stratton, K: Effects of ultraviolet and visible radiation and the production of free radicals in skin. The Biologic Effects of Ultraviolet Radiation 1969 Edited by F Urbach. Oxford, Pergamon Press, pp 207–222,
  4. Henschke, U, Schulze, R: Pigmentation due to long wave ultraviolet. Strahlentherapie 1939 64: 14,
  5. Monash, S: Immediate pigmentation in sunlight and artificial light. Arch Dermatol 1963 87: 686,  | PubMed | ChemPort |
  6. Van der Leun, JC, Stoop, TH: Photorecovery of ultraviolet erythema. The Biologic Effects of Ultraviolet Radiation 1969 Edited by F Urbach. Oxford, Pergamon Press, pp 251–254,
  7. Berger, DS: Specification and design of solar ultraviolet simulators. J Invest Dermatol 1969 53: 192,  | PubMed | ChemPort |
  8. Epstein, JH, Fukuyama, K, Epstein, WL: UVL induced stimulation of DNA synthesis in hairless mouse epidermis. J Invest Dermatol 1968 51: 445,  | PubMed | ChemPort |
  9. Epstein, WL, Fukuyama, K, Epstein, JH: Early effects of ultraviolet light on DNA synthesis in human skin in vivo. Arch Dermatol 1969 100: 84,  | Article | PubMed | ChemPort |
  10. Fukuyama, K, Epstein, WL: Epidermal keratinization: localization of isotopically labeled amino acids. J Invest Dermatol 1966 47: 551,  | PubMed | ChemPort |
  11. Freeman, RG, Owens, DW, Knox, JM: Relative energy requirements for erythemal response of skin to monochromatic wavelengths of ultraviolet present in solar spectrum. J Invest Dermatol 1966 47: 586,  | PubMed | ChemPort |
  12. Bachem, AJ: Time factors of erythema and pigmentation produced by ultraviolet rays of different wavelengths. J Invest Dermatol 1955 25: 215,  | PubMed | ChemPort |
  13. Kligman, AM, Breit, R: The identification of phototoxic drugs by human assay. J Invest Dermatol 1968 51: 90,  | PubMed | ChemPort |
  14. Baden, HP, Pearlman, C: The effect of ultraviolet light on protein and nucleic acid synthesis in the epidermis. J Invest Dermatol 1964 43: 71,  | ISI |
  15. Fukuyama, K, Epstein, WL, Epstein, JH: Effect of ultraviolet light on RNA and protein synthesis in differentiated epidermal cells. Nature (Lond) 1967 216: 1031,  | ChemPort |
  16. Epstein, JH, Fukuyama, K, Fye, K: Effects of ultraviolet radiation on the mitotic cycle and DNA, RNA and protein synthesis in mammalian epidermis in vivo. Photochem Photobiol 1970 12: 57,  | PubMed | ISI | ChemPort |

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