Original Article

Journal of Investigative Dermatology (1972) 59, 402–408; doi:10.1111/1523-1747.ep12627528

XERODERMA PIGMENTOSUM EPIDERMAL CELLS WITH NORMAL UV-INDUCED THYMIDINE INCORPORATION

Jay H Robbins, William R Levis and A Edgar Miller

Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

Received 1 June 1972; Accepted 24 July 1972.

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Abstract

Ultraviolet light-induced thymidine incorporation was measured in trypsin-dissociated epidermal cells from two patients with xeroderma pigmentosum (XP) and from control donors. Results paralleled those obtained with lymphocytes and fibroblasts in that the patient with a repair defect in these cells also had the defect in her epidermal cells. The other patient, previously shown to have no detectable repair defect in his lymphocytes or fibroblasts, appeared also to have normal DNA repair in his epidermal cells despite the presence of severe clinical manifestations of XP in this tissue.

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References

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