Original Article

Journal of Investigative Dermatology (1971) 56, 392–399; doi:10.1111/1523-1747.ep12261282

VEHICLE DESIGN FOR A NEW TROPICAL STEROID, FLUOCINONIDE

James Ostrenga, John Haleblian, Boyd Poulsen, Bonnie Ferrell, Nancy Mueller and Subramanium Shastri

Institue of Pharmaceutical Sciences, Syntex Research, Standford Industrial Park, Palo Alto, California, 94304

Received 11 December 1970; Accepted 8 January 1971.

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Abstract

In vitro release profiles were obtained for eight topical creams containing 0.05% (W/W) fluocinonide, a new topical corticoid. Four of these creams plus five ointments containing 0.05% (W/W) fluocinonide were tested for vehicle efficacy in vivo utilizing a modified Stoughton-McKenzie assay for vasoconstriction. A rank order correlation was obtained between release, percent drug solubilized, and vasoconstrictor response for the creams. A similar correlation existed between percent drug solubilized 1) the significance of vehicle composition. 2) the importance of drug solubility in the vehicle and 3) the usefulness of in vitro release studies in predicting vehicle efficacy.

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References

  1. Ostrenga, JA, Steinmetz, C, Poulsen, BJ: The significance of vehicle composition I. Relationship between topical vehicle composition, skin penetrability, and clinical efficancy. J. Pharm. Sci In press.
  2. Ostrenga, JA, Steinmetz, C, Poulsen, BJ: The significance of vehicle composition II. Prediction of optimal vehicle composition. J. Pharm. Sci In press.
  3. Stoughton, RB: Vasoconstrictor activity and precutaneous absorption of glucocortico-steroids. Arch. Derm 1969 99: 753,  | Article | PubMed | ChemPort |
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  9. Higuchi, WI: Diffusion in ointment bases. p. 162 Proceedings Pharmacy Teachers Seminar 1961

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