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The Journal of Investigative Dermatology (1958) 31, 109–114; doi:10.1038/jid.1958.24

The Failure of Chloroquine to Stimulate the Human Adrenal Cortex1

Supported by United States Army Research Grant DA-49-007-MD-154.

Walter B Shelley MD and Robert P Arthur MD

1 From the Department of Dermatology, University of Pennsylvania, Philadelphia, Pa.

Received 24 December 1957.

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References

  1. Chloroquine-diphosphate-a newly standard-ized antimalarial drug. Bull. U. S. Army M. Dept.7: 834, 1947.
  2. U. S. Dispensatory, ed. Osol, A. and Farrar, G. E. Jr., 2139pp., 25th ed., Phila., Lippin-cott, 1955.
  3. Conan, N. J.: The treatment of hepatic amebiasis with chloroquine. Am. J. Med., 6: 309, 1949.
  4. Puello Garcia, M. J.: Leishmaniasis. Rev. Fac. de med., 17: 338, 1949.
  5. Pillsbury, D. M. and Jacobson, C.: Treatment of chronic discoid lupus erythematosus with chloroquine (Aralen). J.A.M.A., 154: 1330, 1954.
  6. Cahn, M. M., Levy, E. J. and Shaffer, B.: The use of chloroquine diphosphate (Aralen) and quinacrine (Atabrine) hydrochloride in the prevention of polymorphous light eruptions. J. Invest. Dermat., 22: 93, 1954.
  7. Burks, J. W., Jr. and Kingery, F. A. J.: Treatment of creeping eruption with chloroquine disphosphate: a preliminary report. South. M. J., 49: 1290, 1956.
  8. Bagnall, A. W.: The value of chloroquine in rheumatoid disease: A four-year study of continuous therapy. Canad. M. A. J., 77: 182, 1957.
  9. Sanghvi, L. M.: Chloroquine: clinical and electrocardiographic observations after intravenous administration in two cases of auricular fibrillation. Am. Heart J., 52: 908, 1956.
  10. Huff, S. E.: Acrodermatitis chronica atrophi-cans: Report of a case treated with chloroquine phosphate (Aralen). Arch. Dermat., & Syph., 72: 132, 1955.
  11. Ayres, S.III and Ayres, S.Jr.: Chloroquine in treatment of lichen planus and other dermatoses. J.A.M.A., 157: 136, 1955.
  12. Christiansen, J.: Vitiligo treated with chloroquine. Acta dermat.-venereol., 35: 453, 1955.
  13. Brodthagen, H.: Mepacrine and chloroquine in the treatment of rosacea. Brit. J. Dermat., 67: 421, 1955.
  14. Irgang, S.: Sarcoidosis: Treatment with chloroquine diphosphate. Arch. Dermat. & Syph., 75: 150, 1957.
  15. McChesney, E. W., Nachod, F. C. and Tainter, M. L.: Rationale for the treatment of lupus erythematosus with antimalarials. J. Invest. Dermat., 29: 97, 1957.
  16. Cahn, M. M.: Personal communication, 1957.
  17. Parker, F. S. and Irvin, J. L.: The interaction of chloroquine with nucleic acids and nucleoproteins. J. Biol. Chem., 199: 897, 1952. | PubMed | ChemPort |
  18. Kurnick, N. B.: A rational therapy of sys-temic lupus erythematosus. Arch. Int. Med., 79: 562, 1956.
  19. Haydu, G. G.: The inhibition of adenosintri-phosphatase activity in rheumatoid arthritis. Rheumatism, 10: 32, 1954.
  20. Loomis, W. F. and Lipman, F.: Reversible inhibition of the coupling between phosphorylation and oxidation. J. Biol. Chem., 173: 807, 1948. | ISI | ChemPort |
  21. Dawes, G. S.: Synthetic substitutes for quinidine. Brit. J. Pharmacol., 1: 90, 1946.
  22. Agarwal, S. L. and Arora, R. B.: Anticholinergic actions of chloroquine and camoquin on smooth and cardiac muscles. Indian J. M. Research, 44: 631, 1956.
  23. Jindal, M. N.: Effects of quinine, proguanil and chloroquine on cardiovascular responses of adrenaline and acetylcholine in dogs. Indian J. M. Research, 44: 649, 1956.
  24. Langlo, L.: The efficiency of local application of chloroquine and mepacrine in preventing the effects of ultraviolet rays on human skin. Acta dermat.-venereal., 37: 85, 1957.
  25. Tronnier, H. and Azimi-Hamid, A.: Über die UV-Reaktion an der menschlichen Haut. Zeitschr. Haut u. Geschlkr., 22: 1957.
  26. Beal, P. L.: Studies in solar urticaria. J. Invest. Dermat., 11: 415, 1948.
  27. Cahn, M. M., Levy, E. J. and Shaffer, B.: Polymorphous light eruption: The effect of chloroquine phosphate in modifying reactions to ultra-violet light. J. Invest. Dermat., 26: 201, 1956.
  28. Blaich, W. and Gerlach, U.: Zum Wirkungs-mechanismus des Resochin beim Erytnematodes. Hautarzt, 6: 267, 1955.
  29. Nagy, E., Kocsar, L., Jokay, I., Hadhazy, Cs. and Tuza, K.: Neuere Daten zum Wirkungsmechanismus des Atebrins. Der-matologica, 115: 143, 1957.
  30. Leoni, A., Marson, G. and Rossetti, C.: Richerche sperimentali sul meccanismo d'azione della chlorochina: azione della chlorochina sui fenomeni di diffusione. Minerva Derm., 31: 251, 1956.
  31. Alving, A. S., Eichelberger, L., Craige, B.Jr., Jones, R.Jr., Whorton, C. M. and Pullman, T. N.: Studies on the chronic toxicity of chloroquine (Sn-7618). J. Clin. Investigation, 27(part 2): 60, 1948.
  32. Nelson, A. A. and Fitzhugh, O. G.: Chloro-quine (SN-7618) : Pathologic changes observed in rats which for two years had been fed various proportions. Arch. Path., 45: 454, 1948.
  33. Thies, W.: Neuere Erfahrungen bei der Behandlung des Erythematodes chronicus discoides mit Atebrin und Resochin unter Berucksichtigung der localen und kombinierten Behandlungsmethode. Hautarzt., 6: 227, 1955.
  34. Ottolenghi-Lodigiani, F.: Eine Behandlungsart des Lupus erythematodes chronicus: Die ôrtliche intradermale Infiltration mit Acridinpraparaten. Hautarzt., 6: 24, 1955.
  35. Thorn, G. W., Forsham, P. H., Prunty, F. T. G. and Hills, A. G.: A test for adrenal cortical insufficiency. J.A.M.A., 137: 1005, 1948.
  36. Zimmerman, W.: Ein Farbreaktion der Sexual-hormone und ihre Anwendung zur quantitativen colorimetrischen Bestimmung. Ztschr. f. physiol. Chem., 233: 257, 1935.
  37. Silber, R. H. and Porter, C. C: The deter-mination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. J. Biol. Chem., 210: 923, 1954. | PubMed | ISI | ChemPort |
  38. Thorn, G. W., Jenkins, D. and Laidlaw, J. C.: The adrenal response to stress in man. Recent Prog. Hormone Res., 8: . 171, 1953.
  39. Langhof, H. and Muting, D.: Ûber Amino-saurenhaushalt und BAL-Therapie der Lichtdermatosen. Hautarzt., 6: 27, 1955.

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