Commentary
Journal of Investigative Dermatology (2008) 128, 1362–1364. doi:10.1038/sj.jid.5701253
Filaggrin Mutations and Allergic Contact Sensitization
Jon M Hanifin1
1Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Portland, Oregon, USA
Correspondence: Professor Jon M. Hanifin, Department of Dermatology, Oregon Health and Science University, Center for Health and Healing (CH16D), 3303 SW Bond Avenue, Portland, Oregon 97239, USA. E-mail: hanifinj@ohsu.edu
Abstract
In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
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