Letter to the Editor
Subject Category: Genetics
Journal of Investigative Dermatology (2008) 128, 1591–1594; doi:10.1038/sj.jid.5701206; published online 20 December 2007
Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic Eczema
Sara J Brown1,6, Aileen Sandilands2, Yiwei Zhao2, Haihui Liao2, Caroline L Relton3, Simon J Meggitt1, Richard C Trembath4, Jonathan N W N Barker5, Nick J Reynolds1,7, Heather J Cordell6 and W H Irwin McLean2
- 1Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
- 2Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
- 3School of Clinical Medical Sciences (Child Health), Newcastle University, Newcastle upon Tyne, UK
- 4Department of Medical and Molecular Genetics, King's College, London, UK
- 5St John's Institute of Dermatology, King's College London, St Thomas' Hospital, London, UK
- 6Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
- 7Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Correspondence: Sara J. Brown, E-mail: sara.brown@ncl.ac.uk
Abbreviations:
FLG, filaggrin gene
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