Journal of Investigative Dermatology

FIGURE 6

FROM:

Development of Atopic Dermatitis in Mice Transgenic for Human Apolipoprotein C1

Lex Nagelkerken, Perry Verzaal, Tonny Lagerweij, Carla Persoon-Deen, Jimmy F P Berbee, Errol P Prens, Louis M Havekes and Arnold P Oranje

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Figure 6.

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Increased TEWL in APOC1(+/+) mice: effect of lipophilic ointment. (a) TEWL was evaluated in the upper dorsal area of 12-week-old APOC1(+/+) mice left untreated or after treatment by topical application (daily, 3 weeks) with 20% petrolatum in cetomacrogolus cream or a moisturizing cream; APOC1(+/-) mice were included as controls. In a separate experiment, 9-week-old APOC1(+/+) mice were left untreated (filled circles) or treated for a period of 3 weeks with 20% petrolatum in cetomacrogolus cream (open circles), and evaluated with respect to TEWL (b) and the severity of dermatitis according to the TIS score (c).

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