FIGURE 5
FROM:
Development of Atopic Dermatitis in Mice Transgenic for Human Apolipoprotein C1
Lex Nagelkerken, Perry Verzaal, Tonny Lagerweij, Carla Persoon-Deen, Jimmy F P Berbee, Errol P Prens, Louis M Havekes and Arnold P Oranje
BACK TO ARTICLEFigure 5.
Increased epidermal thickening during progression of dermatitis in APOC1(+/+) mice. Heterozygous APOC1(+/-) mice (triangles) or -/- wild-type mice (open circles), which do not develop AD, are included as controls. For each individual mouse, three non-serial sections were evaluated and for each section the epidermal thickness was determined (10 measurements with an interval of 250 
m). For each individual mouse, the average thickness of 30 measurements is shown. For statistical analysis, data obtained in 5- and 6-week-old mice were combined; the same was done for 8- and 9-week-old mice. The Kruskal–Wallis test showed a significant difference between the groups (P<0.00005). At all time points, epidermal thickness was significantly increased (Mann–Whitney U-test, P<0.01) as compared to wild-type mice or APOC1(+/-) mice. Differences as compared to week 5/6 are indicated in the figure.