TABLE OF CONTENTS

Volume 128, Issue 5 (May 2008)

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Editorials

Research Snippets FREE

J Invest Dermatol 128: 1056; doi:10.1038/jid.2008.108

Editors' Picks FREE

J Invest Dermatol 128: 1057; doi:10.1038/jid.2008.83

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Journal Club

Wound Healing without Hair FREE

Yvonne Romagosa, Shasa Hu and Robert S Kirsner

J Invest Dermatol 128: 1058; doi:10.1038/jid.2008.91

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Commentaries

Is the Hair Follicle Necessary for Normal Wound Healing?

Mayumi Ito and George Cotsarelis

J Invest Dermatol 128: 1059-1061; doi:10.1038/jid.2008.86

See also: Original Article by Langton et al.

Modeling Atopic Dermatitis with Increasingly Complex Mouse Models

Tiffany C Scharschmidt and Julia A Segre

J Invest Dermatol 128: 1061-1064; doi:10.1038/sj.jid.5701201

See also: Original Article by Nagelkerken et al.

T-Helper 17 Cells in Psoriatic Plaques and Additional Genetic Links between IL-23 and Psoriasis

Andrew Blauvelt

J Invest Dermatol 128: 1064-1067; doi:10.1038/jid.2008.85

See also: Letter to the Editor by Smith et al.

"Outside-to-Inside" (and Now Back to "Outside") Pathogenic Mechanisms in Atopic Dermatitis

Peter M Elias and Martin Steinhoff

J Invest Dermatol 128: 1067-1070; doi:10.1038/jid.2008.88

See also: Letter to the Editor by Kurahashi et al.
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Perspectives

Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

Maksim V Plikus and Cheng-Ming Chuong

J Invest Dermatol 128: 1071-1080; doi:10.1038/sj.jid.5701180

Controlling Hair Follicle Signaling Pathways through Polyubiquitination

Erik G Huntzicker and Anthony E Oro

J Invest Dermatol 128: 1081-1087; doi:10.1038/sj.jid.5700957

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Original Articles

Appendages

Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression

Adiam W Bahta, Nilofer Farjo, Bessam Farjo and Mike P Philpott

J Invest Dermatol 128: 1088-1094; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701147

Cell Biology

HDAC Activity Is Required for p65/RelA-Dependent Repression of PPARdelta-Mediated Transactivation in Human Keratinocytes

Lene Aarenstrup, Esben Noerregaard Flindt, Kristian Otkjaer, Morten Kirkegaard, Jens Skorstensgaard Andersen and Karsten Kristiansen

J Invest Dermatol 128: 1095-1106; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701146

Potentiation of ATP- and Bradykinin-Induced [ Ca2+] c Responses by PTHrP Peptides in the HaCaT Cell Line

Helen E Burrell, Alec W M Simpson, Sharonpreet Mehat, David T McCreavy, Brian Durham, William D Fraser, Graham R Sharpe and James A Gallagher

J Invest Dermatol 128: 1107-1115; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701159

Hsp27 Regulates Pro-Inflammatory Mediator Release in Keratinocytes by Modulating NF-kappaB Signaling

Runa Sur, Peter A Lyte and Michael D Southall

J Invest Dermatol 128: 1116-1122; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701157

G2A Plays Proinflammatory Roles in Human Keratinocytes under Oxidative Stress as a Receptor for 9-Hydroxyoctadecadienoic Acid

Tomoyasu Hattori, Hideru Obinata, Ai Ogawa, Mikiko Kishi, Kazuaki Tatei, Osamu Ishikawa and Takashi Izumi

J Invest Dermatol 128: 1123-1133; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701172

Clinical Research

NF-kappaB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2

Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke and Martin Leverkus

J Invest Dermatol 128: 1134-1147; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701141

Genetics

Correlation between SPINK5 Gene Mutations and Clinical Manifestations in Netherton Syndrome Patients

Nahoko Komatsu, Kiyofumi Saijoh, Arumugam Jayakumar, Gary L Clayman, Mikiko Tohyama, Yasushi Suga, Yuki Mizuno, Katsuhiko Tsukamoto, Katsushige Taniuchi, Kazuhiko Takehara and Eleftherios P Diamandis

J Invest Dermatol 128: 1148-1159; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701153

Pseudoxanthoma Elasticum: Oxidative Stress and Antioxidant Diet in a Mouse Model (Abcc6 - /- )

Qiaoli Li, Qiujie Jiang and Jouni Uitto

J Invest Dermatol 128: 1160-1164; advance online publication, November 29, 2007; doi:10.1038/sj.jid.5701145

Immunology/Infection

Development of Atopic Dermatitis in Mice Transgenic for Human Apolipoprotein C1

Lex Nagelkerken, Perry Verzaal, Tonny Lagerweij, Carla Persoon-Deen, Jimmy F P Berbee, Errol P Prens, Louis M Havekes and Arnold P Oranje

J Invest Dermatol 128: 1165-1172; advance online publication, November 29, 2007; doi:10.1038/sj.jid.5701182

See also: Commentary by Scharschmidt & Segre
Efalizumab Therapy for Atopic Dermatitis Causes Marked Increases in Circulating Effector Memory CD4+ T Cells That Express Cutaneous Lymphocyte Antigen

Erin G Harper, Eric L Simpson, Rodd H Takiguchi, Miranda D Boyd, Stephen E Kurtz, Antony C Bakke and Andrew Blauvelt

J Invest Dermatol 128: 1173-1181; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701169

Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

Emma Guttman-Yassky, Yulia Vugmeyster, Michelle A Lowes, Francesca Chamian, Toyoko Kikuchi, Mark Kagen, Patricia Gilleaudeau, Edmund Lee, Brisdell Hunte, Kathy Howell, Wolfgang Dummer, Sarah C Bodary and James G Krueger

J Invest Dermatol 128: 1182-1191; advance online publication, January 31, 2008; doi:10.1038/jid.2008.4

Redistribution of LRIG Proteins in Psoriasis

Terese Karlsson, Elisabeth B Mark, Roger Henriksson and Håkan Hedman

J Invest Dermatol 128: 1192-1195; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701175

Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

Taisuke Ito, Natsuho Ito, Matthias Saatoff, Hideo Hashizume, Hidekazu Fukamizu, Brian J Nickoloff, Masahiro Takigawa and Ralf Paus

J Invest Dermatol 128: 1196-1206; advance online publication, December 27, 2007; doi:10.1038/sj.jid.5701183

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

Michelle A Lowes, Toyoko Kikuchi, Judilyn Fuentes-Duculan, Irma Cardinale, Lisa C Zaba, Asifa S Haider, Edward P Bowman and James G Krueger

J Invest Dermatol 128: 1207-1211; advance online publication, January 17, 2008; doi:10.1038/sj.jid.5701213

See also: Commentary by Blauvelt

Keratinocytes/Epidermis

Skin Barrier Disruption by Sodium Lauryl Sulfate-Exposure Alters the Expressions of Involucrin, Transglutaminase 1, Profilaggrin, and Kallikreins during the Repair Phase in Human Skin In Vivo

Hans Törmä, Magnus Lindberg and Berit Berne

J Invest Dermatol 128: 1212-1219; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701170

Melanocytes/Melanoma

BMP-4 Upregulates Kit Expression in Mouse Melanoblasts prior to the Kit-Dependent Cycle of Melanogenesis

Tamihiro Kawakami, Satoko Kimura, Yoko Kawa, Masashi Kato, Masako Mizoguchi and Yoshinao Soma

J Invest Dermatol 128: 1220-1226; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701136

Downregulation of Melanin Synthesis by Haginin A and Its Application to In Vivo Lightening Model

Jin Hee Kim, Seung Hwa Baek, Dong Hyun Kim, Tae Young Choi, Tae Jin Yoon, Jae Sung Hwang, Mee Ree Kim, Ho Jeong Kwon and Choong Hwan Lee

J Invest Dermatol 128: 1227-1235; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701177

Chemical Genetic Screening Identifies Tricyclic Compounds that Decrease Cellular Melanin Content

Li Ni-Komatsu and Seth J Orlow

J Invest Dermatol 128: 1236-1247; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701163

Multiphoton Laser Scanning Microscopy on Non-Melanoma Skin Cancer: Morphologic Features for Future Non-Invasive Diagnostics

John Paoli, Maria Smedh, Ann-Marie Wennberg and Marica B Ericson

J Invest Dermatol 128: 1248-1255; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701139

Neurobiology

Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

Marlon R Schneider, Maria Antsiferova, Laurence Feldmeyer, Maik Dahlhoff, Philippe Bugnon, Sybille Hasse, Ralf Paus, Eckhard Wolf and Sabine Werner

J Invest Dermatol 128: 1256-1265; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701135

LXRalpha Enhances Lipid Synthesis in SZ95 Sebocytes

Il Hong, Min-Ho Lee, Tae-Young Na, Christos C Zouboulis and Mi-Ock Lee

J Invest Dermatol 128: 1266-1272; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701134

The Effects of Acute Social Stress on Epidermal Langerhans' Cell Frequency and Expression of Cutaneous Neuropeptides

C Elise Kleyn, Laura Schneider, Rosita Saraceno, Cristina Mantovani, Helen L Richards, Donal G Fortune, Marie Cumberbatch, Rebecca J Dearman, Giorgio Terenghi, Ian Kimber and Christopher E M Griffiths

J Invest Dermatol 128: 1273-1279; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701144

Identification of Histamine Receptors and Reduction of Squalene Levels by an Antihistamine in Sebocytes

Edward Pelle, James McCarthy, Holger Seltmann, Xi Huang, Thomas Mammone, Christos C Zouboulis and Daniel Maes

J Invest Dermatol 128: 1280-1285; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701160

IGF-1 Induces SREBP-1 Expression and Lipogenesis in SEB-1 Sebocytes via Activation of the Phosphoinositide 3-Kinase/Akt Pathway

Terry M Smith, Kathryn Gilliland, Gary A Clawson and Diane Thiboutot

J Invest Dermatol 128: 1286-1293; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701155

Photobiology

Sunbed Use Induces the Photoaging-Associated Mitochondrial Common Deletion

Verena Reimann, Ursula Krämer, Dorothee Sugiri, Peter Schroeder, Barbara Hoffmann, Kathrin Medve-Koenigs, Karl-Heinz Jöckel, Ulrich Ranft and Jean Krutmann

J Invest Dermatol 128: 1294-1297; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701151

Wound Healing

Gene Profiling of Keloid Fibroblasts Shows Altered Expression in Multiple Fibrosis-Associated Pathways

Joan C Smith, Braden E Boone, Susan R Opalenik, Scott M Williams and Shirley B Russell

J Invest Dermatol 128: 1298-1310; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701149

An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

Abigail K Langton, Sarah E Herrick and Denis J Headon

J Invest Dermatol 128: 1311-1318; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701178

See also: Commentary by Ito & Cotsarelis
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Letters to the Editor

Impact of Homozygosity of R151C Variant of MC1r in Human Hair Follicle Melanocytes

Stéphane F Commo, Olivier Gaillard, Jonathan L Rees and Bruno A Bernard

J Invest Dermatol 128: 1319-1322; advance online publication, December 20, 2007; doi:10.1038/sj.jid.5701181

De Novo Occurrence of the Filaggrin Mutation p.R501X with Prevalent Mutation c.3321delA in a Japanese Family with Ichthyosis Vulgaris Complicated by Atopic Dermatitis

Takahiro Hamada, Aileen Sandilands, Shunpei Fukuda, Sachiko Sakaguchi, Bungo Ohyama, Shinichiro Yasumoto, W H Irwin McLean and Takashi Hashimoto

J Invest Dermatol 128: 1323-1325; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701164

Polymorphisms in the IL-12beta and IL-23R Genes Are Associated with Psoriasis of Early Onset in a UK Cohort

Rhodri Ll Smith, Richard B Warren, Steve Eyre, Pauline Ho, Xiayi Ke, Helen S Young, Christopher E M Griffiths and Jane Worthington

J Invest Dermatol 128: 1325-1327; advance online publication, November 22, 2007; doi:10.1038/sj.jid.5701140

See also: Commentary by Blauvelt

Cidofovir Diphosphate Inhibits Molluscum Contagiosum Virus DNA Polymerase Activity

Takahiro Watanabe and Kunihiko Tamaki

J Invest Dermatol 128: 1327-1329; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701161

IL-4 Suppresses the Recovery of Cutaneous Permeability Barrier Functions In Vivo

Rieko Kurahashi, Yutaka Hatano and Kazumoto Katagiri

J Invest Dermatol 128: 1329-1331; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701138

See also: Commentary by Elias & Steinhoff

Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200

Atsushi Terunuma, Justin W Cross, Michelle Dyke, Veena Kapoor, William G Telford and Jonathan C Vogel

J Invest Dermatol 128: 1332-1334; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701154

Visible Radiation Affects Epidermal Permeability Barrier Recovery: Selective Effects of Red and Blue Light

Mitsuhiro Denda and Shigeyoshi Fuziwara

J Invest Dermatol 128: 1335-1336; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701168

Tumor Biology

Identification of Skn-1n, a Splice Variant Induced by High Calcium Concentration and Specifically Expressed in Normal Human Keratinocytes

Koji Nakajima, Katsuto Tamai, Takehiko Yamazaki, Yuka Toyomaki, Hajime Nakano, Jouni Uitto and Daisuke Sawamura

J Invest Dermatol 128: 1336-1339; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701143

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Erratum

Epidemiologic Support for Melanoma Heterogeneity Using the Surveillance, Epidemiology, and End Results Program FREE

Anne M Lachiewicz, Marianne Berwick, Charles L Wiggins and Nancy E Thomas

J Invest Dermatol 128: 1340-1342; doi:10.1038/jid.2008.18

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