TABLE OF CONTENTS

Volume 128, Issue 4 (April 2008)

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Editorials

Research Snippets FREE

J Invest Dermatol 128: 766; doi:10.1038/jid.2008.47

Editors' Picks FREE

J Invest Dermatol 128: 767; doi:10.1038/jid.2008.46

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Journal Club

Chronic Diseases and Non-Melanoma Skin Cancer: Is There an Association? FREE

Yvonne Romagosa, Shasa Hu and Robert S Kirsner

J Invest Dermatol 128: 768; doi:10.1038/jid.2008.50

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In Memoriam

Charles M. Lapière (1931–2007) FREE

Thomas Krieg

J Invest Dermatol 128: 769-770; doi:10.1038/jid.2008.7

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Commentaries

T-Cell Clonality Assays: How Do They Compare?

Antonio Cozzio and Lars E French

J Invest Dermatol 128: 771-773; doi:10.1038/jid.2008.49

See also: Original Article by Ponti et al.

Vitamin D Regulation of Cathelicidin in the Skin: Toward a Renaissance of Vitamin D in Dermatology?

Siegfried Segaert

J Invest Dermatol 128: 773-775; doi:10.1038/jid.2008.35

See also: Original Article by Schauber et al.
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Perspectives

A Systems Biology Approach to Anatomic Diversity of Skin

John L Rinn, Jordon K Wang, Helen Liu, Kelli Montgomery, Matt van de Rijn and Howard Y Chang

J Invest Dermatol 128: 776-782; doi:10.1038/sj.jid.5700986

The Role of Smads in Skin Development

Philip Owens, Gangwen Han, Allen G Li and Xiao-Jing Wang

J Invest Dermatol 128: 783-790; doi:10.1038/sj.jid.5700969

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Original Articles

Appendages

RSPO4 Is the Major Gene in Autosomal-Recessive Anonychia and Mutations Cluster in the Furin-Like Cysteine-Rich Domains of the Wnt Signaling Ligand R-spondin 4

Nadina Ortiz Brüchle, Jorge Frank, Valeska Frank, Jan Senderek, Ahmet Akar, Erol Koc, Dimitris Rigopoulos, Maurice van Steensel, Klaus Zerres and Carsten Bergmann

J Invest Dermatol 128: 791-796; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701088

Cell Biology

All-trans Retinoic Acid-Induced Hyaluronan Production and Hyperplasia Are Partly Mediated by EGFR Signaling in Epidermal Keratinocytes

Sanna M Pasonen-Seppänen, Edward V Maytin, Kari J Törrönen, Juha M T Hyttinen, Vincent C Hascall, Donald K MacCallum, Anne H Kultti, Tiina A Jokela, Markku I Tammi and Raija H Tammi

J Invest Dermatol 128: 797-807; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701098

Methionine Sulfoxide Reductases A and B Are Deactivated by Hydrogen Peroxide (H2O2) in the Epidermis of Patients with Vitiligo

Karin U Schallreuter, Katharina Rübsam, Nicholas C J Gibbons, Derek J Maitland, Bhaven Chavan, Carsten Zothner, Hartmut Rokos and John M Wood

J Invest Dermatol 128: 808-815; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701100

Histone Acetylation in Keratinocytes Enables Control of the Expression of Cathelicidin and CD14 by 1,25-Dihydroxyvitamin D3

Jürgen Schauber, Yuko Oda, Amanda S Büchau, Qian-Chun Yun, Andreas Steinmeyer, Ulrich Zügel, Daniel D Bikle and Richard L Gallo

J Invest Dermatol 128: 816-824; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701102

See also: Commentary by Segaert
Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

Soline Estrach, Ralf Cordes, Katsuto Hozumi, Achim Gossler and Fiona M Watt

J Invest Dermatol 128: 825-832; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701113

Multiple PKCdelta Tyrosine Residues Are Required for PKCdelta-Dependent Activation of Involucrin Expression—a Key Role of PKCdelta-Y311

Ling Zhu, Chaya Brodie, Sivaprakasam Balasubramanian and Richard L Eckert

J Invest Dermatol 128: 833-845; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701103

Connective Tissue

Propionibacterium acnes Stimulates Pro-Matrix Metalloproteinase-2 Expression through Tumor Necrosis Factor-alpha in Human Dermal Fibroblasts

Jee-Young Choi, Mei Shan Piao, Jee-Bum Lee, Jong Seok Oh, In-Gyu Kim and Seung-Chul Lee

J Invest Dermatol 128: 846-854; advance online publication, November 29, 2007; doi:10.1038/sj.jid.5701188

Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts

Anja Thielitz, Robert W Vetter, Bianca Schultze, Sabine Wrenger, Luca Simeoni, Siegfried Ansorge, Klaus Neubert, Jürgen Faust, Petra Lindenlaub, Harald P M Gollnick and Dirk Reinhold

J Invest Dermatol 128: 855-866; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701104

Genetics

Mutations in R-Spondin 4 (RSPO4) Underlie Inherited Anonychia

Yoshiyuki Ishii, Muhammad Wajid, Hisham Bazzi, Katherine A Fantauzzo, Alison G Barber, Diana C Blaydon, Ju-Suk Nam, Jeong K Yoon, David Peter Kelsell and Angela M Christiano

J Invest Dermatol 128: 867-870; advance online publication, September 6, 2007; doi:10.1038/sj.jid.5701078

Immunology/Infection

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis

Julie Bayle, Jennifer Fitch, Kimberly Jacobsen, Rajiv Kumar, Robert Lafyatis and Raphaël Lemaire

J Invest Dermatol 128: 871-881; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701101

Age-Related Differences in Sensitivity of Peripheral Blood Monocytes to Lipopolysaccharide and Staphylococcus Aureus Toxin B in Atopic Dermatitis

Marie Mandron, Marie-Françoise Ariès, Franck Boralevi, Hélène Martin, Marie Charveron, Alain Taieb and Christian Davrinche

J Invest Dermatol 128: 882-889; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701112

Glove-Derived Foreign Proteins Induce Allergen-Specific IgE in a Mouse Model

Marion Busch, Claudia Schröder, Jens-Malte Baron, Hagen Ott, Thomas Bruckner, Thomas L Diepgen and Vera Mahler

J Invest Dermatol 128: 890-896; advance online publication, November 29, 2007; doi:10.1038/sj.jid.5701126

Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base

Eve Marie Coulter, Claire Jenkinson, Ying Wu, John Farrell, Brian Foster, Andrew Smith, Carolann McGuire, Camilla Pease, David Basketter, Clodagh King, Peter Simon Friedmann, Munir Pirmohamed, Brian Kevin Park and Dean J Naisbitt

J Invest Dermatol 128: 897-905; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701071

Keratinocytes/Epidermis

Regulation of Epidermal Tight-Junctions (TJ) during Infection with Exfoliative Toxin-Negative Staphylococcus Strains

Ulrich Ohnemus, Klaas Kohrmeyer, Pia Houdek, Holger Rohde, Ewa Wladykowski, Sabine Vidal, Matthias A Horstkotte, Martin Aepfelbacher, Nina Kirschner, Martin J Behne, Ingrid Moll and Johanna M Brandner

J Invest Dermatol 128: 906-916; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701070

Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers

Karin M Aberg, Mao-Qiang Man, Richard L Gallo, Tomas Ganz, Debra Crumrine, Barbara E Brown, Eung-Ho Choi, Dong-Kun Kim, Jens M Schröder, Kenneth R Feingold and Peter M Elias

J Invest Dermatol 128: 917-925; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701099

Chronic Diseases Requiring Hospitalization and Risk of Non-Melanoma Skin Cancers—A Population Based Study from Denmark

Annette Ø Jensen, Anne B Olesen, Claus Dethlefsen, Henrik T Sørensen and Margaret R Karagas

J Invest Dermatol 128: 926-931; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701094

IFN-alpha Enhances Poly-IC Responses in Human Keratinocytes by Inducing Expression of Cytosolic Innate RNA Receptors: Relevance for Psoriasis

Errol P Prens, Marius Kant, Grietje van Dijk, Leontine I van der Wel, Sabine Mourits and Leslie van der Fits

J Invest Dermatol 128: 932-938; advance online publication, October 11, 2007; doi:10.1038/sj.jid.5701087

Isolation of Pathogenic Monoclonal Anti-Desmoglein 1 Human Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies

Ken Ishii, Chenyan Lin, Don L Siegel and John R Stanley

J Invest Dermatol 128: 939-948; advance online publication, November 15, 2007; doi:10.1038/sj.jid.5701132

Melanocytes/Melanoma

Hyperthermia Induces Endoplasmic Reticulum-Mediated Apoptosis in Melanoma and Non-Melanoma Skin Cancer Cells

Yiqun G Shellman, William R Howe, Leslie A Miller, Nathaniel B Goldstein, Theresa R Pacheco, Roop L Mahajan, Susan M LaRue and David A Norris

J Invest Dermatol 128: 949-956; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701114

The Multidrug Transporter P-Glycoprotein: A Mediator of Melanoma Invasion?

Marisa Colone, Annarica Calcabrini, Laura Toccacieli, Giuseppina Bozzuto, Annarita Stringaro, Massimo Gentile, Maurizio Cianfriglia, Alessandra Ciervo, Michele Caraglia, Alfredo Budillon, Giuseppina Meo, Giuseppe Arancia and Agnese Molinari

J Invest Dermatol 128: 957-971; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701082

Expression of Ligands to NKp46 in Benign and Malignant Melanocytes

Emanuela Cagnano, Oren Hershkovitz, Alon Zilka, Ahuva Bar-Ilan, Alexandra Golder, Netta Sion-Vardy, Alexander Bogdanov-Berezovsky, Ofer Mandelboim, Daniel Benharroch and Angel Porgador

J Invest Dermatol 128: 972-979; advance online publication, November 1, 2007; doi:10.1038/sj.jid.5701111

mTOR Is Activated in the Majority of Malignant Melanomas

Magdalena Karbowniczek, Cynthia S Spittle, Tasha Morrison, Hong Wu and Elizabeth P Henske

J Invest Dermatol 128: 980-987; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701074

Evaluation of Twenty-One Human Adenovirus Types and One Infectivity-Enhanced Adenovirus for the Treatment of Malignant Melanoma

Dennis Hoffmann, Wibke Bayer, Albert Heim, Anja Potthoff, Dirk M Nettelbeck and Oliver Wildner

J Invest Dermatol 128: 988-998; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701131

Neurobiology

Metabolism and Biological Activities of Topical 4-Oxoretinoids in Mouse Skin

Olivier Sorg, Christian Tran, Pierre Carraux, Denise Grand, Christelle Barraclough, Jean-François Arrighi, Patrick Descombes, Vincent Piguet and Jean-Hilaire Saurat

J Invest Dermatol 128: 999-1008; advance online publication, October 18, 2007; doi:10.1038/sj.jid.5701106

Dynamic Expression of Erbb Pathway Members during Early Mammary Gland Morphogenesis

Olivia Wansbury, Heena Panchal, Michelle James, Suzanne Parry, Alan Ashworth and Beatrice Howard

J Invest Dermatol 128: 1009-1021; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701118

Photobiology

UVB-Induced Activation of NF-kappaB is Regulated by the IGF-1R and Dependent on p38 MAPK

Davina A Lewis and Dan F Spandau

J Invest Dermatol 128: 1022-1029; advance online publication, December 6, 2007; doi:10.1038/sj.jid.5701127

Tumor Biology

TCRbold gamma-Chain Gene Rearrangement by PCR-Based GeneScan: Diagnostic Accuracy Improvement and Clonal Heterogeneity Analysis in Multiple Cutaneous T-Cell Lymphoma Samples

Renata Ponti, Maria T Fierro, Pietro Quaglino, Bonello Lisa, Francia di Celle Paola, Ortoncelli Michela, Fava Paolo, Alessandra Comessatti, Mauro Novelli and Maria G Bernengo

J Invest Dermatol 128: 1030-1038; advance online publication, November 8, 2007; doi:10.1038/sj.jid.5701109

See also: Commentary by Cozzio & French

Wound Healing

A Murine Living Skin Equivalent Amenable to Live-Cell Imaging: Analysis of the Roles of Connexins in the Epidermis

Eve E Kandyba, Malcolm B Hodgins and Patricia E Martin

J Invest Dermatol 128: 1039-1049; advance online publication, October 25, 2007; doi:10.1038/sj.jid.5701125

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Letter to the Editor

Somatic Mutation Analysis in NF1 Café au lait Spots Reveals Two NF1 Hits in the Melanocytes

Sofie De Schepper, Ophélia Maertens, Tom Callens, Jean-Marie Naeyaert, Jo Lambert and Ludwine Messiaen

J Invest Dermatol 128: 1050-1053; advance online publication, October 4, 2007; doi:10.1038/sj.jid.5701095

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