Commentary
Journal of Investigative Dermatology (2008) 128, 773–775. doi:10.1038/jid.2008.35
Vitamin D Regulation of Cathelicidin in the Skin: Toward a Renaissance of Vitamin D in Dermatology?
Siegfried Segaert1
1Department of Dermatology, University Hospital Leuven, Belgium
Correspondence: Dr Siegfried Segaert, UZ Sint-Rafaël, Kapucijnenvoer 33, B-3000 Leuven, Belgium. E-mail: Siegfried.Segaert@med.kuleuven.be
Abstract
1,25-Dihydroxyvitamin D3, the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.
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