Commentary
Journal of Investigative Dermatology (2008) 128, 2569–2571. doi:10.1038/jid.2008.283
A Role for Th17 Cells in the Immunopathogenesis of Atopic Dermatitis?
Antonella Di Cesare1,2, Paola Di Meglio1 and Frank O Nestle1
- 1St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom
- 2Department of Dermatology, University of L'Aquila L'Aquila, Italy
Correspondence: Professor Frank O. Nestle, St John's Institute of Dermatology, King's College London School of Medicine, Floor 9, Tower Wing, Guy's Hospital, London SE1 9RT, United Kingdom. E-mail: frank.nestle@kcl.ac.uk
Abstract
Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.
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