Journal of Investigative Dermatology

FIGURE 8

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Versican, a Major Hyaluronan-Binding Component in the Dermis, Loses its Hyaluronan-Binding Ability in Solar Elastosis

Keiko Hasegawa, Masahiko Yoneda, Hiroko Kuwabara, Osamu Miyaishi, Naoki Itano, Akiko Ohno, Masahiro Zako and Zenzo Isogai

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Figure 8.

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Hyaluronidase activity is not detected in solar elastosis. To exclude the possibility that activated hyaluronidase activity in solar elastosis reduced the accumulation of hyaluronan, skin pieces from normal and solar elastosis skin were minced and incubated with hyaluronan. The treated samples were sieved and the concentrations of HA measured. Incubation with normal skin and solar elastosis skin did not affect the size or amount of HA. Incubation with Streptomyces hyaluronidase completely abolished HA (not shown in the graph).

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