Commentary
Journal of Investigative Dermatology (2007) 127, 1572–1573; doi:10.1038/sj.jid.5700772
FGFR3 Mutations in Epidermal Nevi and Seborrheic Keratoses: Lessons from Urothelium and Skin
Christian Hafner1, Arndt Hartmann2 and Thomas Vogt1
- 1Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
- 2Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
Correspondence: Dr Christian Hafner, Department of Dermatology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany. E-mail: christian.hafner@klinik.uni-regensburg.de
Abstract
Somatic FGFR3 mutations have been reported in various cancers such as urothelial carcinoma. Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses. The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3 related tumors in urothelium and skin.
