TABLE OF CONTENTS

Volume 127, Issue 6 (June 2007)

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Editorials

Welcome to Our Home! FREE

Editor Paul R Bergstresser

J Invest Dermatol 127: 1277-1278; doi:10.1038/sj.jid.5700877

Research Snippets FREE

J Invest Dermatol 127: 1280; doi:10.1038/sj.jid.5700905

Editors' Picks FREE

J Invest Dermatol 127: 1281; doi:10.1038/sj.jid.5700867

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Commentaries

Filaggrin's Fuller Figure: A Glimpse into the Genetic Architecture of Atopic Dermatitis FREE

Aileen Sandilands, Frances J D Smith, Alan D Irvine and W H Irwin McLean

J Invest Dermatol 127: 1282-1284; doi:10.1038/sj.jid.5700876

Common Ground?: Tetracyclines, Matrix Metalloproteinases, Pustular Dermatoses, and Loxoscelism FREE

Lloyd E King Jr.

J Invest Dermatol 127: 1284-1286; doi:10.1038/sj.jid.5700724

See also: Original Article by Paixão-Cavalcante et al.

Cross-Linking of Elafin/SKALP to Elastic Fibers in Photodamaged Skin: Too Much of a Good Thing? FREE

Joost Schalkwijk

J Invest Dermatol 127: 1286-1287; doi:10.1038/sj.jid.5700691

See also: Original Article by Muto et al.

Opioids and the Skin: "Itchy" Perspectives beyond Analgesia and Abuse FREE

Martin Schmelz and Ralf Paus

J Invest Dermatol 127: 1287-1289; doi:10.1038/sj.jid.5700634

See also: Original Article by Bigliardi-Qi et al.

Clues from Alopecia Areata on the Role of Neuropeptides in the Initiation of Autoimmunity FREE

Richard S Kalish

J Invest Dermatol 127: 1289-1291; doi:10.1038/sj.jid.5700655

See also: Original Article by Siebenhaar et al.
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Review

Genetics

Mouse Models of Psoriasis FREE

Johann E Gudjonsson, Andrew Johnston, Melissa Dyson, Helgi Valdimarsson and James T Elder

J Invest Dermatol 127: 1292-1308; advance online publication, April 12, 2007; doi:10.1038/sj.jid.5700807

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Original Articles

Appendages

Expression of Lipogenic Factors Galectin-12, Resistin, SREBP-1, and SCD in Human Sebaceous Glands and Cultured Sebocytes FREE

Wesley J Harrison, Jonathan J Bull, Holger Seltmann, Christos C Zouboulis and Michael P Philpott

J Invest Dermatol 127: 1309-1317; advance online publication, March 15, 2007; doi:10.1038/sj.jid.5700743

Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells FREE

Masato Iino, Ritsuko Ehama, Yosuke Nakazawa, Tokuro Iwabuchi, Masashi Ogo, Masahiro Tajima and Seiji Arase

J Invest Dermatol 127: 1318-1325; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700728

Cell Biology

IL-20 Gene Expression Is Induced by IL-1beta through Mitogen-Activated Protein Kinase and NF-kappaB-Dependent Mechanisms FREE

Kristian Otkjaer, Knud Kragballe, Claus Johansen, Anne T Funding, Helle Just, Uffe B Jensen, Lotte G Sørensen, Peder L Nørby, Jes T Clausen and Lars Iversen

J Invest Dermatol 127: 1326-1336; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700713

Clinical Research

Increased Blood Levels of IgG Reactive with Secreted Streptococcus pyogenes Proteins in Chronic Plaque Psoriasis FREE

Rana G El-Rachkidy, Jonathan M Hales, Primrose P E Freestone, Helen S Young, Christopher E M Griffiths and Richard D R Camp

J Invest Dermatol 127: 1337-1342; advance online publication, March 8, 2007; doi:10.1038/sj.jid.5700744

Sun-Protective Behaviors in Families at Increased Risk of Melanoma FREE

Julia A Newton Bishop, Tamara Taylor, Henry W W Potts, Faye Elliott, Elizabeth Pinney, Jennifer H Barrett, D Timothy Bishop and Lesley Fallowfield

J Invest Dermatol 127: 1343-1350; advance online publication, March 8, 2007; doi:10.1038/sj.jid.5700764

Quality-of-Life Outcomes of Treatments for Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma FREE

Mary-Margaret Chren, Anju P Sahay, Daniel S Bertenthal, Saunak Sen and C Seth Landefeld

J Invest Dermatol 127: 1351-1357; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700740

Connective Tissue

Accumulation of Elafin in Actinic Elastosis of Sun-Damaged Skin: Elafin Binds to Elastin and Prevents Elastolytic Degradation FREE

Jun Muto, Kei Kuroda, Hiroshi Wachi, Shigehisa Hirose and Shingo Tajima

J Invest Dermatol 127: 1358-1366; advance online publication, November 30, 2006; doi:10.1038/sj.jid.5700647

See also: Commentary by Schalkwijk

Genetics

Loss-of-Function Variants of the Filaggrin Gene Are Not Major Susceptibility Factors for Psoriasis Vulgaris or Psoriatic Arthritis in German Patients FREE

Ulrike Hüffmeier, Heiko Traupe, Vinzenz Oji, Jesús Lascorz, Markward Ständer, Jörg Lohmann, Jörg Wendler, Harald Burkhardt and André Reis

J Invest Dermatol 127: 1367-1370; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700720

Keratin 1 Gene Mutation Detected in Epidermal Nevus with Epidermolytic Hyperkeratosis FREE

Akiko Tsubota, Masashi Akiyama, Kaori Sakai, Maki Goto, Yukiko Nomura, Satomi Ando, Masataka Abe, Daisuke Sawamura and Hiroshi Shimizu

J Invest Dermatol 127: 1371-1374; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700712

Mutation in Mpzl3, a Gene Encoding a Predicted the Adhesion Protein, in the Rough Coat (rc) Mice with Severe Skin and Hair Abnormalities FREE

Tongyu Cao, Peter Racz, Kornelia M Szauter, Gergely Groma, Garrett Y Nakamatsu, Benjamin Fogelgren, Eszter Pankotai, Qing-Ping He and Katalin Csiszar

J Invest Dermatol 127: 1375-1386; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700706

BRAF Mutations in Multiple Sebaceous Hyperplasias of Patients Belonging to MYH-Associated Polyposis Pedigrees FREE

Giovanni Ponti, Tiziana Venesio, Lorena Losi, Giovanni Pellacani, Lucio Bertario, Paola Sala, Monica Pedroni, Consalvo Petti, Stefania Maffei, Liliana Varesco, Erika Lerch, Andrea Baggio, Sara Bassoli, Caterina Longo and Stefania Seidenari

J Invest Dermatol 127: 1387-1391; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700723

Aberrant Mineralization of Connective Tissues in a Mouse Model of Pseudoxanthoma Elasticum: Systemic and Local Regulatory Factors FREE

Qiujie Jiang, Qiaoli Li and Jouni Uitto

J Invest Dermatol 127: 1392-1402; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700729

Confirmation of Psoriasis Susceptibility Loci on Chromosome 6p21 and 20p13 in French Families FREE

Fabienne Lesueur, Caroline Lefèvre, Cristina Has, Michel Guilloud-Bataille, Tiphaine Oudot, Emmanuel Mahé, Morad Lahfa, Samira Mansouri, Haydeh Mosharraf-Olmolk, Eric Sobel, Simon Heath, Mark Lathrop, Marie-Hélène Dizier, Jean-François Prud'Homme and Judith Fischer

J Invest Dermatol 127: 1403-1409; advance online publication, March 8, 2007; doi:10.1038/sj.jid.5700749

Immunology/Infection

Tetracycline Protects against Dermonecrosis Induced by Loxosceles Spider Venom FREE

Danielle Paixão-Cavalcante, Carmen W van den Berg, Rute M Gonçalves-de-Andrade, Matheus de F Fernandes-Pedrosa, Cinthya Kimori Okamoto and Denise V Tambourgi

J Invest Dermatol 127: 1410-1418; advance online publication, January 11, 2007; doi:10.1038/sj.jid.5700688

See also: Commentary by King
Targeting Effector Memory T Cells with the Small Molecule Kv1.3 Blocker PAP-1 Suppresses Allergic Contact Dermatitis FREE

Philippe Azam, Ananthakrishnan Sankaranarayanan, Daniel Homerick, Stephen Griffey and Heike Wulff

J Invest Dermatol 127: 1419-1429; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700717

Skin Contact Irritation Conditions the Development and Severity of Allergic Contact Dermatitis FREE

Marlene Bonneville, Cyril Chavagnac, Marc Vocanson, Aurore Rozieres, Josette Benetiere, Ingrid Pernet, Alain Denis, Jean-Francois Nicolas and Ana Hennino

J Invest Dermatol 127: 1430-1435; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700726

C34, a Membrane Fusion Inhibitor, Blocks HIV Infection of Langerhans Cells and Viral Transmission to T Cells FREE

Makoto Sugaya, Oliver Hartley, Michael J Root and Andrew Blauvelt

J Invest Dermatol 127: 1436-1443; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700736

Constitutive Expression and Regulated Release of the Transmembrane Chemokine CXCL16 in Human and Murine Skin FREE

Felix Scholz, Alexander Schulte, Frederic Adamski, Christian Hundhausen, Jens Mittag, Agatha Schwarz, Marie-Luise Kruse, Ehrhardt Proksch and Andreas Ludwig

J Invest Dermatol 127: 1444-1455; advance online publication, March 15, 2007; doi:10.1038/sj.jid.5700751

Keratinocytes/Epidermis

Differential Regulation of Karyopherin alpha 2 Expression by TGF-beta 1 and IFN-bold italic gamma in Normal Human Epidermal Keratinocytes: Evident Contribution of KPNA2 for Nuclear Translocation of IRF-1 FREE

Noriko Umegaki, Katsuto Tamai, Hajime Nakano, Ryuta Moritsugu, Takehiko Yamazaki, Katsumi Hanada, Ichiro Katayama and Yasufumi Kaneda

J Invest Dermatol 127: 1456-1464; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700716

Melanocytes/Melanoma

Novel CDKN2A Mutations Detected in Western Swedish Families with Hereditary Malignant Melanoma FREE

Anna Erlandson, Frida Appelqvist, Ann-Marie Wennberg, Joanna Holm and Charlotta Enerbäck

J Invest Dermatol 127: 1465-1467; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700718

Chromosomal Translocations as a Mechanism of BRAF Activation in Two Cases of Large Congenital Melanocytic Nevi FREE

Barbara Dessars, Linda E De Raeve, Hakim El Housni, Catherine J Debouck, Pierre J Sidon, Renato Morandini, Diane Roseeuw, Ghanem E Ghanem, Gilbert Vassart and Pierre Heimann

J Invest Dermatol 127: 1468-1470; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700725

Improper Trafficking of Melanocyte-Specific Proteins in Hermansky–Pudlak Syndrome Type-5 FREE

Amanda Helip-Wooley, Wendy Westbroek, Heidi M Dorward, Amy Koshoffer, Marjan Huizing, Raymond E Boissy and William A Gahl

J Invest Dermatol 127: 1471-1478; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700737

Neurobiology

Deletion of mu- and kappa-Opioid Receptors in Mice Changes Epidermal Hypertrophy, Density of Peripheral Nerve Endings, and Itch Behavior FREE

Mei Bigliardi-Qi, Claire Gaveriaux-Ruff, Katrin Pfaltz, Pierre Bady, Tommy Baumann, Theo Rufli, Brigitte L Kieffer and Paul L Bigliardi

J Invest Dermatol 127: 1479-1488; advance online publication, December 21, 2006; doi:10.1038/sj.jid.5700661

See also: Commentary by Schmelz & Paus
Substance P as an Immunomodulatory Neuropeptide in a Mouse Model for Autoimmune Hair Loss (Alopecia Areata) FREE

Frank Siebenhaar, Andrey A Sharov, Eva M J Peters, Tatyana Y Sharova, Wolfgang Syska, Andrei N Mardaryev, Pia Freyschmidt-Paul, John P Sundberg, Marcus Maurer and Vladimir A Botchkarev

J Invest Dermatol 127: 1489-1497; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700704

See also: Commentary by Kalish

Photobiology

Direct Detection of Singlet Oxygen Generated by UVA Irradiation in Human Cells and Skin FREE

Jürgen Baier, Tim Maisch, Max Maier, Michael Landthaler and Wolfgang Bäumler

J Invest Dermatol 127: 1498-1506; advance online publication, March 15, 2007; doi:10.1038/sj.jid.5700741

Depletion of CD4+ Cells Exacerbates the Cutaneous Response to Acute and Chronic UVB Exposure FREE

Jennifer L Hatton, Allison Parent, Kathleen L Tober, Tyler Hoppes, Brian C Wulff, F Jason Duncan, Donna F Kusewitt, Anne M VanBuskirk and Tatiana M Oberyszyn

J Invest Dermatol 127: 1507-1515; advance online publication, March 15, 2007; doi:10.1038/sj.jid.5700746

Tumor Biology

In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma FREE

Patrick Micke, Kai Kappert, Mitsuhiro Ohshima, Christina Sundquist, Stefan Scheidl, Per Lindahl, Carl-Henrik Heldin, Johan Botling, Fredrik Ponten and Arne Östman

J Invest Dermatol 127: 1516-1523; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700714

Wound Healing

Burn Injury Reveals Altered Phenotype in Mannan-Binding Lectin-Deficient Mice FREE

Mette Møller-Kristensen, Michael R Hamblin, Steffen Thiel, Jens Chr Jensenius and Kazue Takahashi

J Invest Dermatol 127: 1524-1531; advance online publication, March 15, 2007; doi:10.1038/sj.jid.5700748

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Letters to the Editor

Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog FREE

Lutz Langbein, Michael A Rogers, Silke Praetzel-Wunder, Dittmar Böckler, Peter Schirmacher and Jürgen Schweizer

J Invest Dermatol 127: 1532-1535; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700734

Filaggrin R501X and 2282del4 Mutations Are Not Associated with Chronic Plaque-Type Psoriasis in a German Cohort FREE

Michael Weichenthal, Andreas Ruether, Stefan Schreiber, Rajan Nair, John J Voorhees, Thomas Schwarz, Dietrich Kabelitz, Enno Christophers, James T Elder and Stefan Jenisch

J Invest Dermatol 127: 1535-1537; advance online publication, March 22, 2007; doi:10.1038/sj.jid.5700771

Possible Involvement of Exon 31 Alternative Splicing in Phenotype and Severity of Epidermolysis Bullosa Caused by Mutations in PLEC1  FREE

Daisuke Sawamura, Maki Goto, Kaori Sakai, Hideki Nakamura, James R McMillan, Masashi Akiyama, Osamu Shirado, Noritaka Oyama, Masataka Satoh, Fumio Kaneko, Toshiaki Takahashi, Hidehiko Konno and Hiroshi Shimizu

J Invest Dermatol 127: 1537-1540; advance online publication, February 1, 2007; doi:10.1038/sj.jid.5700707

A Novel GJB2 Mutation p.Asn54His in a Patient with Palmoplantar Keratoderma, Sensorineural Hearing Loss and Knuckle Pads FREE

Masashi Akiyama, Kaori Sakai, Ken Arita, Yukiko Nomura, Kei Ito, Kazuo Kodama, James R McMillan, Kinuko Kobayashi, Daisuke Sawamura and Hiroshi Shimizu

J Invest Dermatol 127: 1540-1543; advance online publication, January 25, 2007; doi:10.1038/sj.jid.5700711

Colchicine Promotes Antigen Cross-Presentation by Murine Dendritic Cells FREE

Norikatsu Mizumoto, Hiroaki Tanaka, Hironori Matsushima, Mridula Vishwanath and Akira Takashima

J Invest Dermatol 127: 1543-1546; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700699

A Mechanistic Study of delta-Aminolevulinic Acid-Based Photodynamic Therapy for Cutaneous Leishmaniasis FREE

Sachiko Kosaka, Oleg E Akilov, Katie O'Riordan and Tayyaba Hasan

J Invest Dermatol 127: 1546-1549; advance online publication, January 11, 2007; doi:10.1038/sj.jid.5700719

Nuclear c-Myc: A Molecular Marker for Early Stage Pemphigus Vulgaris FREE

Lina Williamson, Thomas Hunziker, Maja M Suter and Eliane J Müller

J Invest Dermatol 127: 1549-1555; advance online publication, February 22, 2007; doi:10.1038/sj.jid.5700735

Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood FREE

Salvador A Benitah and Fiona M Watt

J Invest Dermatol 127: 1555-1557; advance online publication, February 15, 2007; doi:10.1038/sj.jid.5700738

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